School of Clinical Medicine (ETDs)
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Item From the onset: Impact of Nutrition and Lifestyle during the Preconception period in Urban South African Young Adults(University of the Witwatersrand, Johannesburg, 2023-03) Mukoma, Gudani Goodman; Norris, Shane A.Background: In South Africa, 22% of adolescents are overweight or obese, the onset of tobacco smoking is shown to peak between the ages of 15 and 22, 1 in 3 adolescents watch more than 3 hours of television per day, and nearly half of all adults are insufficiently active. Physical inactivity, poor diet, risky alcohol use, illicit drug use are among the behavioural risk factors associated with obesity and mental health problems, all of which have morbidity and mortality implications for adult health. Risks in later life include premature death, long-term disability, childbirth complications, gestational diabetes, diabetes and cardiovascular diseases. However, there is data paucity showing the personal, social, and environmental factors that are determinants of health, especially diet, physical activity (PA), obesity, and associated NCDs in South African adolescents and young adults. Aim: To investigate the individual, household, and environmental factors that influence adolescents' dietary and physical activity habits and to identify ways in which these factors can be leveraged for interventions to better ensure the health of future generations, especially during the crucial preconception years. Methods: This thesis was purposely designed to use a sequential mixed-methods approach that integrates quantitative (Chapter 3 paper 1: cross-sectional and Chapter 6 paper 4: longitudinal) and qualitative (Chapter 4 paper 2: longitudinal and Chapter 5 paper 3: cross-sectional) analyses in order to meet the four specific objectives of my research. The methods selected for this series of investigations were primarily influenced by the substantive research questions that arose, as opposed to methodological and epistemological concerns alone. I utilized three pre-existing data sources, including the "Birth-to-Twenty Cohort," the "Determinants of Type 2 Diabetes Mellitus (T2D)" study, and the "Soweto household enumeration survey." I have gathered new prospective data that is quantitatively and qualitatively longitudinal and cross-sectional. Results: The findings of this thesis in the context of Soweto show that the relationship between dietary patterns and nutritional status (BMI) is independent of socioeconomic status (SES). Adolescents and young adults face a variety of intersecting barriers resulting from personal preferences and their living conditions, which influence their dietary and physical activity habits while occurring at the time; this is important to consider when designing interventions to promote healthy behaviour change. Unexpected stressors, such as the outbreak of the COVID-19 pandemic, contributed to exacerbating adolescents' and young adults' poor health conditions, and as a result, the prevalence of poor nutrition intake, a lack of physical activity, and mental health issues increased. Although the nutrient patterns of adolescents and adults were comparable over time, their associations with BMI were not. The associations with BMI of the "plant-driven nutrient pattern," "fat-driven nutrient pattern," and "animal-driven nutrient pattern" revealed sex differences. Conclusion: Adolescent diet and lifestyle continue to be important research areas in the intent to enhance preconception health and reducing maternal and infant mortality.Item Nutrition of ageing black South African women and correlates with anthropometry and cardiometabolic outcomes(University of the Witwatersrand, Johannesburg, 2023-09) Kankwende, Caroline Belinda Tsitsi; Gradidge, Philippe; Norris, Shane; Chikowore, TinasheBackground: Obesity is most prevalent among black women who reside in urban areas in South Africa yet the nutrient patterns of this cohort of women has never been investigated, nor have correlates of body composition indices such as adiposity and body mass index (BMI). These body composition indices are important to analyse as they have been shown to be positively associated with hypertension which is prevalent in this cohort of women. Aim: There were three main goals: 1) To determine the baseline nutrient patterns of middle-aged black South African women residing in Soweto and correlates to body composition indices 2) To evaluate the longitudinal association of nutrient patterns with adiposity in a cohort of middle-aged black South African women over a period of 5.5- years 3) To elucidate the longitudinal associations of nutrient patterns and blood pressure and to explore whether this is an indirect effect mediated by body mass index (BMI) using structural equation modelling Methods: A longitudinal study of children and their families, originally called the Birth to Twenty Plus (Bt20+) cohort and now referred to as the Middle-aged Soweto Cohort (MASC), was used to as the original dataset for this thesis. This study also drew on another embedded study, the Study of Women Entering and in Endocrine Transition (SWEET) study of older women transitioning through menopause. Data on (i) dietary information; (ii) body composition and anthropometry measurements; (iii) blood pressure; (iv) lifestyle behaviours (physical activity, tobacco use, and alcohol use); (v) psychosocial factors; (vi) socioeconomic status; and (vii) educational status were used. A total of 498 Women aged between 40 and 60 years old were included in the study. Principle component analysis (PCA) was applied on the dietary data both at baseline and at 5- years follow-up. This was conducted to extract nutrient patterns from 25 nutrients derived from the food frequency questionnaire (FFQ) and the resulting nutrient patterns are detailed in results chapter 3 (nutrient patterns derived from the baseline FFQ) and results chapter 4 (comparison between both baseline and follow-up nutrient patterns from the FFQ). Simple and complex body composition were recorded for each participant with complex body measurements taken using (DXA). Chapter 3 details the results of the 3 baseline nutrient patterns and correlates with body composition parameters. Using generalized estimating equations, associations between both baseline and 5- years follow-up nutrient patterns and adiposity were evaluated. The results are discussed in results chapter 4. Lastly, the results chapter 5 examined associations between both baseline and follow-up nutrient patterns and blood pressure were examined and furthermore, investigated whether BMI mediates the relationship between repeated measures of nutrient patterns and blood pressure. Results: The majority of the research participants (88%) were classified as individuals having obese status defined by their BMI. The fat mass index (FMI), lean mass index (LMI), gynoid fat, hip and waist circumference, and visceral and subcutaneous adipose tissue (VAT and SAT respectively) measurements were all substantially larger in the group with predominantly individuals having overweight and obese classification compared to woman in the lean group (p <0.001). Protein consumption was greater in the group with individuals having overweight/obese classification, while fat and carbohydrate consumption were matched. At baseline, the "Plant driven nutrient pattern," characterized by higher factor loadings of plant protein, starch, and B vitamins, explained 25% of the total nutritional variance; the "Animal protein driven nutrient pattern," characterized by animal protein and saturated fat, explained 23% of the variance; and the third pattern was the "Vitamin C, sugar and potassium driven nutrient pattern," which had higher factor loadings of vitamin C, sugar and potassium. At baseline, increased consumption of the animal protein driven nutrient pattern resulted in a 1.19 kg/m2 (p = 0.002) increase in BMI, 10.17 cm2 for VAT, 24.43 cm2 for SAT, 0.01 (p = 0.009) increase for VAT/SAT ratio, 0.69 kg/m2 (p = 0.005) increase for FMI, and 0.48 kg/m2 (p = 0.002) increase for LMI. Furthermore at baseline, statistically significant associations were found for the animal protein driven nutrient pattern with all body composition indicators. Subcutaneous adipose tissue increased in the presence of a plant-driven nutrition pattern (p = 0.045). At 5-year follow-up, although the value of the factor loadings of the individual nutrients changed between baseline and follow-up, the nutrients with the highest loadings for each principal component (PC) did not change therefore the overall nutrient patterns remained the same. Only DXA-derived measurements of fat mass, FMI, VAT, and gynoid fat mass (FM) increased with time, while lean mass considerably reduced. Repeated measures of the animal protein driven nutrient pattern was associated with significant increases in FMI, LMI and VAT and repeated measures of the vitamin C, sugar, and potassium driven nutrient pattern was significantly associated with an increase in FMI and LMI. For the purposes of this study, repeated measures of animal-driven nutrient patterns were shown to be significantly related with repeated measures of systolic blood pressure (SBP) only. When structural equation modelling (SEM) was applied, only significant relationships were observed between age and SBP. This relationship was not mediated by BMI but may involve other factors that were not included in this analysis. Conclusions: This thesis explored the nutrient patterns linked to obesity and cardiometabolic complications, namely blood pressure, in a cohort of black middle-aged African females. It has been previously demonstrated that this cohort has been has a high prevalence of obesity. According to literature reviews, programs focusing on nutritional and behavioural changes could aid African women in their fight against the obesity and hypertension epidemic that we are facing today. The animal-driven nutrient pattern was found to be substantially associated with increases in body fat in this cohort at baseline. At 5-year follow-up, the nutrient patterns remained the same and repeated measurements of the vitamin C, sugar, and potassium-driven nutrient pattern were associated with significant increases in FMI and LMI and the animal-driven nutrient pattern remained significantly associated with LMI, FMI and VAT, a measure of visceral obesity which is a major risk factor for cardiometabolic conditions. This is problematic in a population that consists predominantly of individuals that are classified as having an obese and overweight status. As a result of a higher BMI, a greater likelihood of developing cardiometabolic multimorbidity exists which is defined as the co-occurrence of two or three cardiometabolic conditions. This may result in reduced quality of life and an increased burden on the already overstretched healthcare system in South Africa. Furthermore, this study found that only the animal protein driven nutrient pattern had a significant relationship with SBP which was significant. When SEM was applied, BMI did not mediate the relationship between blood pressure and any of the nutrient patterns. No other noteworthy direct relationships between blood pressure and the other nutrient patterns were found. Researchers can apply the findings of this study to improve nutritional policies and guidelines aimed at combating not just obesity, but high blood pressure among black women in Sub-Saharan Africa. It is necessary to conduct further extensive research to verify these findings.Item Role of novel biomarkers in predicting chronic kidney disease progression among black patients attending a tertiary hospital in Johannesburg, South Africa(University of the Witwatersrand, Johannesburg, 2023) Meremo, Alfred Jackson; Naicker, Saraladevi; Duarte, Raquel; Paget, Graham; Dickens, CarolineBackground: Chronic kidney disease (CKD) is a leading health issue and its magnitude has been increasing globally; where the developing countries are the most affected and they are the least equipped to deal with its associated consequences. Chronic kidney disease can rapidly and quietly progress to late CKD stages in impoverished environments. Early recognition of patients who are likely to develop end-stage kidney disease (ESKD) is important. Methodology: A prospective longitudinal study was conducted on CKD patients of black ethnicity attending at the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) renal outpatient clinic in South Africa, as from September 2019 to March 2022. Patients provided blood and urine samples for investigations in the laboratory at study enrolment (0) and at the 24 months follow up. The concentrations of the transforming growth factor isoforms [(TGF)-β1, TGF-β2 and TGF-β3) were determined in serum and urine at baseline using the Human TGF-β duoset ELISA. Data were descriptively and inferentially processed by the REDcap and analyzed using STATA version 17 and multivariable logistic regression analysis was applied to find out the predictors of CKD progression. Results: A total of 312 patients were recruited into the study; the median age was 58 (IQR 46 -67) years and 162 (51.9 %) were male. Hypertension was present in majority (96.7 %) of the patients. Diabetes mellitus was present in 38.7 % of patients and 38.1 % of the study patients had both hypertension and diabetes mellitus. A total of 297 (95.2%) patients completed the study. Death was reported in 5 (1.6%) patients and 10 (3.2%) of patients were lost to follow up. The prevalence of CKD progression was 49.5%, 33% had CKD remission and 17.5% had CKD regression while the prevalence of CKD progression by change in uPCR > 30% was 51.9%. Almost half (47.8 %) had a sustained decline in eGFR of > 4 ml/min/1.73 m2 /year or more, 35.0% of the patients moved to a more severe stage of CKD and 19.9% had more than 30% 6 decline in eGFR in two years. For patients with CKD progression, 54.9% patients were men and at baseline, their median age was 59 (46 - 67) years, urine protein creatinine ratio (uPCR) increased at 0.039 (0.015-0.085) g/mmol, eGFR was 37 (32 -51) mL/min/1.73 m2; the median serum TGF-β1 was 21210 (15915 – 25745) ng/L and the median urine TGF-β3 was 17.5 (5.4 –76.2) ng/L. For those who had CKD progression, hypertension was present in the majority (95.2%) of the patients. Diabetes mellitus was present in 59 (40.1%) patients and 58 (39.5%) patients had both hypertension and diabetes mellitus; 48.3% had severely increased proteinuria, 45.6% patients had anaemia, 34.0% had hyperuricemia and 17.7% had hypocalcaemia at baseline. For those patients with CKD progression vs those without CKD progression, the baseline median serum TGF-β1 was 21210 (15915 – 25745) ng/L vs 24200 (17570 – 29560) ng/L, the baseline median urine TGF-β3 was 17.5 (5.4 – 76.2) ng/L vs 2.8 (1.8 – 15.3) ng/L; however, baseline serum and urine TGF-β isoforms did not predict progression of CKD on univariate and multivariable analyses. Regarding use of medications among patients with CKD progression, calcium channel blockers (amlodipine) were used by majority (85.2 %) of the patients. Diuretics were used by 63.4% of the patients and 31.7 % of the patients were using insulin. Variables associated with CKD progression after multivariable logistic regression analysis were moderately elevated proteinuria (OR 2.1, 95% CI (1.1 – 3.9), P= 0.019), severely elevated proteinuria (OR 6.1, 95 % CI (3.2 – 11.6), P = 0.001), hyponatraemia (OR 4.5, 95% CI 1.8 - 23.6, P= 0.042), hypocalcaemia (OR 3.8, 95 % CI 1.0 - 14.8, P = 0.047), anaemia (OR 2.1, 95% CI 1.0 - 4.3, P= 0.048), elevated HbA1c (OR 1.8, 95 % CI 1.2 - 2.8, P = 0.007), diabetes mellitus (OR 1.8, 95 % CI 1.9 - 3.6, P = 0.047), current smoking (OR 2.8, 95 % CI 1.9 - 8.6, P = 0.049), medications which were calcium channel blockers (OR 2.07, 95 % CI 1.04 – 4.12, P = 0.038), diuretics (OR 2.35, 95 % CI 1.37 – 4.00, P = 0.002), insulin (OR 1.96, 95 % CI 1.01 – 3.84, P = 0.048) and baseline serum calcium levels (OR 0.06, 95 % CI 0.01 -0.64, P = 0.019). An increase in uPCR > 30% at two years identified most patients with CKD progression; clinicians and nephrologists should utilize change in uPCR > 30% at two years to identify those patients with CKD who are likely to progress more rapidly, who require closer surveillance and monitoring with emphasis on slowing or stopping progression of the CKD. Conclusion: Our study has demonstrated a higher prevalence of CKD progression in a prospective longitudinal study among black patients than that reported in previous studies. CKD progression was associated with current smoking, hyponatremia, hypocalcemia, anaemia, elevated HbA1c, diabetes mellitus, and proteinuria. While patients with CKD progression had lower baseline concentrations of serum TGF-β1 and increased baseline urinary TGF-β3 concentrations, baseline serum and urine TGF-β isoforms did not predict progression of CKD. The roles of the various serum and urine TGF-β isoforms in CKD progression at baseline are still unclear and highlight the importance of further studies to determine their isoform specific effects.Item Predicting in-hospital mortality in heart failure patients using machine learning(University of the Witwatersrand, Johannesburg, 2023-05) Mpanya, Dineo; Ntsinjana, HopewellThe age of onset and causes of heart failure differ between high-income and low-and-middle-income countries (LMIC). Heart failure patients in LMIC also experience a higher mortality rate. Innovative ways that can risk stratify heart failure patients in this region are needed. The aim of this study was to demonstrate the utility of machine learning in predicting all-cause mortality in heart failure patients hospitalised in a tertiary academic centre. Six supervised machine learning algorithms were trained to predict in-hospital all-cause mortality using data from 500 consecutive heart failure patients with a left ventricular ejection fraction (LVEF) less than 50%. The mean age was 55.2 ± 16.8 years. There were 271 (54.2%) males, and the mean LVEF was 29 ± 9.2%. The median duration of hospitalisation was 7 days (interquartile range: 4–11), and it did not differ between patients discharged alive and those who died. After a prediction window of 4 years (interquartile range: 2–6), 84 (16.8%) patients died before discharge from the hospital. The area under the receiver operating characteristic curve was 0.82, 0.78, 0.77, 0.76, 0.75, and 0.62 for random forest, logistic regression, support vector machines (SVM), extreme gradient boosting, multilayer perceptron (MLP), and decision trees, and the accuracy during the test phase was 88, 87, 86, 82, 78, and 76% for random forest, MLP, SVM, extreme gradient boosting, decision trees, and logistic regression. The support vector machines were the best performing algorithm, and furosemide, beta-blockers, spironolactone, early diastolic murmur, and a parasternal heave had a positive coefficient with the target feature, whereas coronary artery disease, potassium, oedema grade, ischaemic cardiomyopathy, and right bundle branch block on electrocardiogram had negative coefficients. Despite a small sample size, supervised machine learning algorithms successfully predicted all-cause mortality with modest accuracy. The SVM model will be externally validated using data from multiple cardiology centres in South Africa before developing a uniquely African risk prediction tool that can potentially transform heart failure management through precision medicine.Item A retrospective study on the outcomes of peripartum hysterectomies for puerperal sepsis at Chris Hani Baragwanath Academic Hospital(University of the Witwatersrand, Johannesburg, 2024) Olusola, Esther; Naidoo, PoovangelaBackground: Puerperal sepsis is a significant cause of maternal morbidity and mortality, especially in developing countries. Hysterectomy is often performed as a measure of source control for severe uterine infections when conservative treatment fails. The aim of this retrospective study was to examine the outcomes of peripartum hysterectomies performed for puerperal sepsis at Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa. Methods: A retrospective cross-sectional study was conducted between 1 January and 31 December 2019, on all women who underwent hysterectomies for puerperal sepsis. Data pertaining to demographics, surgical characteristics, microbiological cultures, organ dysfunction scores, and histopathological findings, were extracted from medical records. Women with miscarriages or pregnancies less than 24 weeks’ gestation were excluded. Statistical analysis included descriptive methods and comparative tests using Stata 15.0 software. Organ dysfunction scores were calculated using MODS, SOFA, and qSOFA systems. Ethical approval was obtained prior to conduction of the study. Results: During the study period, 33 hysterectomies were performed for puerperal sepsis, representing 0.17% of the 18,458 deliveries at the hospital. The median age of women was 28 years of age with a median gestational age at delivery of 38 weeks. The majority (88%) underwent total abdominal hysterectomies, while 12% had subtotal hysterectomies. Eighty eight percent of women underwent caesarean section for a fetal distress. The most common organisms cultured in intra-abdominal fluid were Acinetobacter baumannii (26%), Escherichia coli (19%), Klebsiella species (14%) and Enterococcus faecalis (14%). A. baumannii was the predominant pathogen in all four culture mediums. The most common antibiotics used in this hospital for treatment were resistant against most organisms. Women with higher MODS and SOFA scores predominantly cultured resistant organisms. A. baumannii was strongly associated with worse outcomes. Two women (6%) died due to complications of ongoing sepsis. Histological examination revealed that surgeons often underestimated the extent of necrosis (30%) and presence of pus (44%), highlighting the importance of histopathological evaluation for accurate diagnosis and management. Conclusion: This study highlights the rising antibiotic resistance which complicates treatment and emphasises the need for revision of antibiotic stewardship in puerperal sepsis management. Women with higher MODS and SOFA scores predominantly cultured resistant organisms. Further research is required to explore improving surgical recognition of uterine sepsis and whether a total abdominal hysterectomy is actually superior to a subtotal hysterectomy in women with puerperal sepsis.Item Patterns of HIV Resistance in Children Attending an Antiretroviral Clinic in Soweto, South Africa: A Case-Control Study(University of the Witwatersrand, Johannesburg, 2023) Vilakazi, Zinhle; Moore, David Paul; Sipambo, Nosisa; Steegen, KimBackground: Exposure to suboptimal serum levels of antiretrovirals (ARVs) places resistance pressure on circulating human immunodeficiency virus (HIV), with consequent emergence of resistance. HIV resistance leads to treatment failure and adverse outcomes. We explored factors associated with the emergence of ARV resistance in children living with HIV (CLWH) attending a treatment clinic in Soweto. Methods: We reviewed the clinical and laboratory characteristics, and factors associated with ARV resistance in children aged 0 to 15 years of age that were treated at the clinic from 01 January 2011 through 31 December 2020. The Stanford HIV drug resistance database was used to identify HIV drug resistance mutations and generate resistance profiles. Characteristics of children that underwent drug resistance testing (DRT) were compared to those of children who remained virologically suppressed on fist-line ARVs. Results: During the study period, 7,029 children attended the clinic of which 425 (6.0%) underwent DRT (cases) and 953 (13.6%) remained suppressed on first-line ARVs (controls). The resistance dataset included 431 resistance tests that were done in 425 children and adolescents that were eligible for the study. Non-nucleoside reverse transcriptase inhibitor (NNRTI) mutations accounted for 50.8% of all mutations, followed by nucleoside reverse transcriptase inhibitor (NRTI) mutations (44.5%) and protease inhibitor (PI) mutations (4.6%). Cases were significantly older at ARV initiation (81.6 vs 45.2 months), had a higher prevalence of ever being diagnosed with tuberculosis (33.2% vs 27.4%), ever being orphaned (57.6% vs 50.6%) and ever experiencing severe acute malnutrition (SAM) (19.8% vs 11.7%). In all modelling approaches, SAM was consistently associated with ARV resistance adjusted odds ratios (aOR) ranging from 3.548 (95% confidence interval (CI) 1.979-6.359) to 6.383 (95% CI, 3.811-10.690)). Increasing baseline CD4 percentage was associated with significantly lower adjusted odds of case-status aOR ranging from 0.971 (95% CI, 0.953-0.989) to 0.951 (95% CI, 0.931-0.972)). Seventeen (5.6%) cases died, compared to two (0.3%) controls; P<0.001. Conclusions: Tenuous nutritional status was consistently and significantly associated with the requirement for DRT in this cohort of children and adolescents. Conversely, higher baseline CD4 percentage was associated with control status. Early ARV initiation, to preserve immunological status, and nutritional support throughout the course of clinic attendance may limit the emergence of drug resistance in CLWH.Item Voiding cystourethrography in the renal pre-transplantation workup: an essential investigation?(University of the Witwatersrand, Johannesburg, 2022-10) Sofianos, Zelia; Rajkumar, Leisha; Lucas, SusanINTRODUCTION: Due to resource constraints in the South African public healthcare sector, patients with End-Stage Renal Disease (ESRD) are eligible for renal replacement therapy only if they are also found to be eligible for renal transplant. AIM: The aim of this study is to document Voiding Cystourethrogram (VCUG) findings in potential renal transplant candidates to assess the contribution of the VCUG as a standard investigation in the renal transplant workup. METHODS: Of the patients who underwent VCUG in Klerksdorp/Tshepong Hospital Complex (North West province, South Africa) from 1 January 2019 to 31 March 2020, 85 patients were included in the study and their VCUG findings retrospectively analysed. RESULTS: The mean age was 40.0 years (range 21-62 years), with males constituting 57.7% of patients and females 42.3%. Lower urinary tract abnormalities were identified in 24.7% of patients, some of whom had more than one abnormality. Of the total abnormalities, VUR (vesicoureteral reflux) accounted for 15.3%, bladder diverticula for 5.9%, urethral strictures for 3.5% and a significant post-void residual volume for 4.7%. No comorbidities were found to have a statistically significant association with the presence of VCUG abnormalities. CONCLUSIONS: To ensure that patients with End-Stage Renal Disease are adequately prepared for renal dialysis and potential renal transplant, and that their comorbidities and lower urinary tract are optimised should abnormalities be identified on VCUG, the VCUG remains an essential investigation in the renal transplant workup.Item Emergency Department Turnover Intention: Are Job Satisfaction and Burnout Really the Main Culprits?(University of the Witwatersrand, Johannesburg, 2022-11) Jonker, Yvonne Denise; Motara, Feroza; Moolla, MuhammedBackground: Patient presentations to emergency departments (ED) keep increasing. High staff turnover is detrimental to the healthcare worker (HCW), the organisation and the patient. While high levels of burnout (BO) and low levels of job satisfaction (JS) lead to a higher intention to leave (ItL), there are other factors affecting the ItL that need to be evaluated. Objective: To determine the levels of BO, JS and ItL, including when, where and why HCWs want to leave in order to find ways to reduce staff turnover. Methods: This was a prospective observational cross-sectional study conducted in two tertiary-level EDs in Johannesburg, South Africa namely Chris Hani Baragwanath Academic Hospital (CHBAH) and Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). Doctors and nurses were invited to complete self-administered questionnaires between 24 November 2020 and 24 March 2021. After analysis the results for doctors and nurses and the two units were compared in order to bring understanding to the different facets affecting staff turnover. Results: A total of 78 respondents (66% of doctors and 58% of nurses) completed questionnaires and were included for analysis. According to the Copenhagen Burnout Inventory 79% of CHBAH doctors, 62% of CHBAH nurses, 79% of CMJAH doctors and 84% of CMJAH nurses suffered from severe personal burnout, while 68% of CHBAH doctors, 62% of CHBAH nurses, 95% of CMJAH doctors and 68% of CMJAH nurses suffered from severe work-related BO and 42% for CHBAH doctors, 24% of CHBAH nurses, 47% of CMJAH doctors and 32% of CMJAH nurses had severe patient-related burnout. Doctors had significantly higher patient-related burnout (p=0.012). JS was average for all staff but nurses were significantly less satisfied (p=0.003). While 42% of staff intended to leave within a year, of which half wanted to leave as soon as possible, a total of 73 % wanted to leave within 5 years. CMJAH staff had higher levels of BO, lower levels of JS and higher levels of ItL. Higher levels of BO and lower levels of JS increased the ItL. The main reasons for leaving were career-related. Conclusion: Burnout levels were higher than similar populations before and during the Covid-19 pandemic, while job satisfaction levels were average. Although burnout and job satisfaction affected intention to leave, the main reasons for wanting to leave were career-related indicating that even when work conditions and burnout could be addressed successfully, the turnover of staff in tertiary level EDs may remain high.Item Analysis of Orthopaedic Injuries in Polytrauma Patients at Charlotte Maxeke Johannesburg Academic Hospital(University of the Witwatersrand, Johannesburg, 2022) Laney, Wezley; Naicker, Dharshen; Milner, BrendaBackground: Traumatic injuries represent a significant burden globally, accounting for ten percent of the global burden of disease. In South Africa we commonly see patients who have sustained major trauma, often with multiple injuries. This significant burden of trauma necessitates the demand for rapid diagnostic assessment of injuries for appropriate therapeutic intervention. A whole body computed tomography (CT pan scan) allows for a rapid multisystem injury diagnosis of trauma patients. There is a scarcity of literature evaluating the extent of orthopaedic injuries in polytrauma patients. Study Aim: The aim of the study was to evaluate the local epidemiology of orthopaedic injuries in polytrauma patients who have undergone a CT pan scan. Methods: A retrospective, observational analysis, based at Charlotte Maxeke Johannesburg Academic Hospital, was done of polytrauma patients who underwent a CT pan scan, during a 2-year period from 01/01/2018 – 31/12/2019. A database was compiled by accessing the picture archiving and communication system for CT reports. The qualitative data was reported using frequencies and percentages. Categorical variables were analysed using the Chi-squared test (or Fisher’s exact test). Results: Over the two-year study period a total of 296 polytrauma patients had a reported CT pan scan performed. Of these, 85% were male and 15% were female with a median age of 33 years. The most common mechanism of injury was motor vehicle accidents (33.1%). The prevalence of orthopaedic injuries in polytrauma patients was 53.3%. A total of 1012 injuries were found. One hundred and ninety-six (196) spinal fractures were detected; a total of 137 pelvic/sacral fractures, 101 long bone fractures with 75% lower limbs and 25% were upper limb fractures. The most common non-orthopaedic injury sustained was a chest injury. The most common combination of orthopaedic and non-orthopaedic injuries identified in the study was a chest injury with an associated pelvic/sacral fracture secondary to a PVA. Interpersonal and intentional injuries were significantly associated with a higher risk of thoracic spine fractures (RR 1.8, CI 1.1-2.9). Road traffic accidents were significantly associated with a higher risk of scapular/clavicular fractures (RR 2.0, CI 1.2-3.5) and a higher risk of tibial/fibula fractures (RR 3.5, CI 1.2-10.3) Conclusion: The majority of polytrauma patients seen at CMJAH were young males, who sustained injuries during road traffic accidents. Fractures accounted for 94% of all orthopaedic injuries. The most common orthopaedic injury detected in our cohort, overall, was a spinal fracture, most commonly involving the cervical spine. A patient involved in a road traffic accident is 3.5 times more likely to sustain a tibia/fibular fracture as opposed to any other fracture. The most common non-orthopaedic injury sustained was a chest injury. Importantly, 1 in 4 of these patients sustained an associated cervical spine injury and 1 in 3 a pelvic injury, similarly with head injuries. The most common combination of injuries is a chest injury with an associated pelvic/sacral fracture secondary to a pedestrian vehicle accident. The findings highlight the significant burden of orthopaedic injuries in polytrauma patients. In addition, the findings of this study, highlight injury patterns that should be anticipated in polytrauma patients.Item Maternal death at Leratong Regional Hospital: a six-year retrospective review, South Africa(University of the Witwatersrand, Johannesburg, 2021-11) Motau, Tumelo Ngaka; Chauke, LawrenceBackground: The aim of the study was to systematically examine the main causes of maternal deaths and contributing factors at Leratong Regional Hospital in order to recommend strategies that can assist in reducing maternal mortality at this level of healthcare. Objectives: The objectives of the study were to: determine the institutional maternal mortality rate at Leratong Regional Hospital between 2012 to 2017, compare the trend (year on year) in the iMMR over the study period, describe the profile of women who died during the period under study, describe the clinical and surgical management of the women who died, and to determine the leading causes of maternal deaths, contributing factors and avoidable factors. Methods: A hospital based retrospective study based on patient clinical records at Leratong hospital. It included all the maternal deaths that occurred at Leratong Regional Hospital during the six-year study period (2012-2017). Results: There was a total of 78 maternal deaths with 32441 live births giving the MMR of 240 per 100 000 live births. However only 74 files could be analysed. The results showed that there was a rise in the maternal mortality rate over a six years period. The majority (70, 94.5%) of the women who died were African, aged between 20-35 years (56, 76%), multigravida (54,73%) with a parity of three or more (23, 31%). Obstetric haemorrhage was the leading cause of maternal death particularly postpartum haemorrhage (11.14%) followed by non-pregnancy related infections, sepsis and eclampsia. Conclusion: Maternal mortality has decreased according to recent confidential enquiry into maternal death in South Africa (2017-2019) However our study did not demonstrate a decline but rather an increase in the maternal mortality rate at Leratong. It showed that most of the maternal deaths were avoidable and the need for urgent interventions in terms of education, improving access to health care facilities, intensifying health care worker skills training and better transport systems between health care facilities is important.