Extensively Drug-Resistant Acinetobacter baumannii Complex (XDR-AB) Colonisation and Clinical Outcome in Neonates: A Retrospective Case-Control Study
| dc.contributor.author | Phambane, Gugulethu Julia | |
| dc.date.accessioned | 2026-04-28T07:36:14Z | |
| dc.date.issued | 2025 | |
| dc.description | A research report submitted in fulfillment of the requirements for the Master of Medicine in Clinical Microbiology, in the Faculty of Health Sciences, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, 2025 | |
| dc.description.abstract | Extensively drug-resistant Acinetobacter baumannii (XDR-AB) is a significant cause of healthcare-associated infections, particularly in neonatal intensive care units (NICUs). This study aimed to determine the prevalence of XDR-AB colonisation and the odds of subsequent invasive infection. The secondary objective was to identify risk factors and in-hospital outcomes. We investigated 485 neonates admitted at Rahima Moosa Mother and Child Hospital from 1 June 2020 to 31 December 2022. Among them, 116 (23.92%) were colonised with XDR-AB, with a median colonisation age of 4 days. Of these, 29 (25%) developed invasive disease, and 12 (10.34%) died. Mechanical ventilation increased the risk of colonisation by 2.28 times. The study highlights the high prevalence of early colonisation and associated mortality, emphasizing the need for screening, vigilant monitoring, and tailored antibiotic treatment for colonized neonates | |
| dc.description.submitter | MM2026 | |
| dc.faculty | Faculty of Health Sciences | |
| dc.identifier.citation | Phambane, Gugulethu Julia . (2025). Extensively Drug-Resistant Acinetobacter baumannii Complex (XDR-AB) Colonisation and Clinical Outcome in Neonates: A Retrospective Case-Control Study [Master’s dissertation, University of the Witwatersrand, Johannesburg]. WIReDSpace. https://hdl.handle.net/10539/49111 | |
| dc.identifier.uri | https://hdl.handle.net/10539/49111 | |
| dc.language.iso | en | |
| dc.publisher | University of the Witwatersrand, Johannesburg | |
| dc.rights | © 2025 University of the Witwatersrand, Johannesburg. All rights reserved. The copyright in this work vests in the University of the Witwatersrand, Johannesburg. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of University of the Witwatersrand, Johannesburg. | |
| dc.rights.holder | University of the Witwatersrand, Johannesburg | |
| dc.school | School of Clinical Medicine | |
| dc.subject | UCTD | |
| dc.subject | Extensively drug-resistant Acinetobacter baumannii | |
| dc.subject | colonisation | |
| dc.subject | invasive disease | |
| dc.subject | risk factors | |
| dc.subject.primarysdg | SDG-3: Good health and well-being | |
| dc.title | Extensively Drug-Resistant Acinetobacter baumannii Complex (XDR-AB) Colonisation and Clinical Outcome in Neonates: A Retrospective Case-Control Study | |
| dc.type | Dissertation |