Dynamic compartmentalised heat transfer modelling for systems with biological applications

dc.contributor.authorXu, Lan
dc.contributor.supervisorMoodley, Prebantha
dc.contributor.supervisorHildebrandt, Diane
dc.date.accessioned2025-04-02T10:46:17Z
dc.date.issued2023
dc.descriptionA research report Submitted in fulfillment of the requirements for Science in Chemical Engineering to the Faculty of Engineering & Built Environment, School of Chemical engineering, University of the Witwatersrand, Johannesburg 2023
dc.description.abstractProper thermal management is crucial to controlling the temperature of biological systems within an optimized operating range. A biological system is comprised of a multitude of interacting facets, where a system is often disrupted as a consequence of random events such as the change in ambient temperature. In contrast the design of most human engineered chemical systems or processes may assume steady state operation and as a result is relatively straightforward to design and optimise. Yet, often steady temperature ranges are required in unsteady conditions. This sort of unsteady state system requires consideration of the dynamic changes to the conditions and are often required to be within many applications. A narrow temperature band is essential for controlling the outcomes of how biological systems’ function—thermal denaturation of biological components depend on precise control of the transport of heat. Insulin—a hormone peptide drug—is temperature sensitive and undergoes thermal fibrillation when exposed to temperatures above manufacturers' recommendations. To maintain such medication within specific temperature bands is a challenge in the face of energy intermittency from the energy crisis that South Africa is currently facing. Within this dissertation, a medical device to contain thermosensitive biological compounds is designed and modelled as a system undergoing dynamic thermal conditions. This heat transfer modelling is used as a prototyping process for designing the medical device to protect temperature sensitive medication during power outages. The simulated device, when used correctly, is able to keep medication thermally stable under 8°C during Stage 4 load shedding (7.5 hours of power outages within a 24-hour period).
dc.description.sponsorshipNational Research Fund
dc.description.sponsorshipmerSETA
dc.description.submitterMM2025
dc.facultyFaculty of Engineering and the Built Environment
dc.identifierhttps://orcid.org/ 0000-0003-1342-4710
dc.identifier.citationXu, Lan. (2023). Dynamic compartmentalised heat transfer modelling for systems with biological applications [Master’s dissertation, University of the Witwatersrand, Johannesburg].WireDSpace.https://hdl.handle.net/10539/44555
dc.identifier.urihttps://hdl.handle.net/10539/44555
dc.language.isoen
dc.publisherUniversity of the Witwatersrand, Johannesburg
dc.rights© 2025 University of the Witwatersrand, Johannesburg. All rights reserved. The copyright in this work vests in the University of the Witwatersrand, Johannesburg. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of University of the Witwatersrand, Johannesburg.
dc.rights.holderUniversity of the Witwatersrand, Johannesburg
dc.schoolSchool of Chemical and Metallurgical Engineering
dc.subjectDynamic compartmentalised
dc.subjectbiological applications
dc.subjectheat transfer modelling
dc.subject.primarysdgSDG-9: Industry, innovation and infrastructure
dc.titleDynamic compartmentalised heat transfer modelling for systems with biological applications
dc.typeDissertation

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