Incidence and Transmission Dynamics of Bordetella pertussis Infection in Rural and Urban Communities, South Africa, 2016‒2018

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dc.contributor.authorFahima Moosa
dc.contributor.authorStefano Tempia
dc.contributor.authorJackie Kleynhans
dc.contributor.authorMeredith McMorrow
dc.contributor.authorJocelyn Moyes
dc.contributor.authorMignon du Plessis
dc.contributor.authorMaimuna Carrim
dc.contributor.authorFlorette K. Treurnicht
dc.contributor.authorOrienka Helfersee
dc.contributor.authorThulisa Mkhencele
dc.contributor.authorAzwifarwi Mathunjwa
dc.contributor.authorNeil A. Martinson
dc.contributor.authorKathleen Kahn
dc.contributor.authorLimakatso Lebina
dc.contributor.authorFloidy Wafawanaka
dc.contributor.authorCheryl Cohen
dc.contributor.authorAnne von Gottberg
dc.contributor.authorNicole Wolter
dc.date.accessioned2024-02-28T11:57:05Z
dc.date.available2024-02-28T11:57:05Z
dc.date.issued2023-02-02
dc.description.abstractWe conducted 3 prospective cohort studies (2016–2018), enrolling persons from 2 communities in South Africa. Nasopharyngeal swab specimens were collected twice a week from participants. Factors associated with Bordetella pertussis incidence, episode duration, and household transmission were determined by using Poisson regression, Weibull accelerated time-failure, and logistic regression hierarchical models, respectively. Among 1,684 participants, 118 episodes of infection were detected in 107 participants (incidence 0.21, 95% CI 0.17–0.25 infections/100 person-weeks). Children <5 years of age who had incomplete vaccination were more likely to have pertussis infection. Episode duration was longer for participants who had higher bacterial loads. Transmission was more likely to occur from male index case-patients and persons who had >7 days infection duration. In both communities, there was high incidence of B. pertussis infection and most cases were colonized.
dc.description.librarianPM2023
dc.facultyFaculty of Health Sciences
dc.identifier.urihttps://hdl.handle.net/10539/37726
dc.language.isoen
dc.schoolPublic Health
dc.titleIncidence and Transmission Dynamics of Bordetella pertussis Infection in Rural and Urban Communities, South Africa, 2016‒2018
dc.typeArticle
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