Incidence and Transmission Dynamics of Bordetella pertussis Infection in Rural and Urban Communities, South Africa, 2016‒2018
Date
2023-02-02
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
We conducted 3 prospective cohort studies (2016–2018),
enrolling persons from 2 communities in South Africa.
Nasopharyngeal swab specimens were collected twice
a week from participants. Factors associated with Bordetella pertussis incidence, episode duration, and household transmission were determined by using Poisson
regression, Weibull accelerated time-failure, and logistic regression hierarchical models, respectively. Among
1,684 participants, 118 episodes of infection were detected in 107 participants (incidence 0.21, 95% CI 0.17–0.25
infections/100 person-weeks). Children <5 years of age
who had incomplete vaccination were more likely to have
pertussis infection. Episode duration was longer for participants who had higher bacterial loads. Transmission
was more likely to occur from male index case-patients
and persons who had >7 days infection duration. In both
communities, there was high incidence of B. pertussis
infection and most cases were colonized.