Antiphospholipid Syndrome Screening Results and Associated Obstetric Outcomes at Rahima Moosa Mother and Child Hospital
| dc.contributor.author | Hela, Simamkele Siviwe | |
| dc.date.accessioned | 2026-02-16T06:56:49Z | |
| dc.date.issued | 2024 | |
| dc.description | A research report submitted in fulfillment of the requirements for the Master of Medicine, in the Faculty of Health Sciences, School of Medicine, University of the Witwatersrand, Johannesburg, 2024 | |
| dc.description.abstract | Background Antiphospholipid syndrome (APS) is an autoimmune disease associated with venous and arterial thrombosis and adverse pregnancy outcomes that include recurrent early miscarriage, fetal death, early onset preeclampsia and placental insufficiency. However, there is limited data on APS prevalence and its impact in Africa. Objectives This study aimed to investigate the prevalence of APS by laboratory criteria and its obstetric outcomes among pregnant women accessing care at Rahima Moosa Mother and Child Hospital (RMMCH) in Johannesburg, South Africa. Methods: Medical records of patients who were tested for at least two of the following – ACLA, LA, aB2GP1 and ANA between July 1, 2019, and December 31, 2019. Results: There were 511 patients who were tested for APS during the study period and 123 records were available for analysis. Only 2 (1.6%) met the diagnostic criteria for APS in the 123 records and 5 (0.84%) of the 511 patients met the diagnostic criteria. Conclusion: Despite the challenges associated with diagnosing APS, this study emphasises on the importance of screening for other conditions that may result in poor fetal and neonatal outcomes other than antiphospholipid syndrome, | |
| dc.description.submitter | MM2026 | |
| dc.faculty | Faculty of Health Sciences | |
| dc.identifier | 0009-0003-7089-9808 | |
| dc.identifier.citation | Hela, Simamkele Siviwe . (2024). Antiphospholipid Syndrome Screening Results and Associated Obstetric Outcomes at Rahima Moosa Mother and Child Hospital [Master`s dissertation, University of the Witwatersrand, Johannesburg]. WIReDSpace. https://hdl.handle.net/10539/48017 | |
| dc.identifier.uri | https://hdl.handle.net/10539/48017 | |
| dc.language.iso | en | |
| dc.rights | © 2024 University of the Witwatersrand, Johannesburg. All rights reserved. The copyright in this work vests in the University of the Witwatersrand, Johannesburg. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of University of the Witwatersrand, Johannesburg. | |
| dc.rights.holder | University of the Witwatersrand, Johannesburg | |
| dc.school | School of Clinical Medicine | |
| dc.subject | UCTD | |
| dc.subject | Antiphospholipid syndrome | |
| dc.subject | Neonatal death | |
| dc.subject | Anitbodies | |
| dc.subject.primarysdg | SDG-3: Good health and well-being | |
| dc.title | Antiphospholipid Syndrome Screening Results and Associated Obstetric Outcomes at Rahima Moosa Mother and Child Hospital | |
| dc.type | Dissertation |