3. Electronic Theses and Dissertations (ETDs) - All submissions
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Item The influence of fatty acids in vitro on mammalian cells from species differing in their fatty acyl desaturase capabilities. Volume. 2(1991-12) Gianngregorio, AlfredoNumerous studies have assessed the effects of single fatty acids on various aspects of lipid metabolism, particularly cancer. Established cell lines have largely been used for this purpose. The choice of control cells, however, has often been inappropriate. There is also a surprising lack of knowledge of the effects of fatty acids in the 'real world", in which normal cells in vivo are presented with mixtures of dietary fatty acids. Before transformed cells can be used as models of disease states, it is essential to fully understand fatty acid metabolism in normal (control) cellsItem A study of some aspects of the metabolism of fatty acids by the human red blood cell in health and disease, with special reference to diabetes mellitus(1962-11) Mendelsohn, DennisThe awakening of an appreciation of the importance of biochemistry to medical science in recent years has prompted the clinical chemist to study and explain disease mechanisms in terms of fundamental cellular metabolism. However these efforts have been considerably hampered by obvious difficulties involved in obtaining suitable tissues for experimental purposes. Most of our rather meagre understanding of the underlying mechanisms causing metabolic diseases in the human subject has been obtained by absolute chemical analysis of the body fluids of which it is probably true to say that the blood ( either whole blood or serum ) has been the most extensively studied. It is becoming increasingly apparent however, that this type of approach does not offer a satisfactory explanation for the disturbed metabolic reactions in certain diseases