A study of some aspects of the metabolism of fatty acids by the human red blood cell in health and disease, with special reference to diabetes mellitus
Date
1962-11
Authors
Mendelsohn, Dennis
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Abstract
The awakening of an appreciation of the importance of biochemistry to medical science in recent years has prompted the clinical chemist to study and explain disease mechanisms in terms of fundamental cellular metabolism. However these efforts have been considerably hampered by obvious difficulties involved in obtaining suitable tissues for experimental purposes. Most of our rather meagre understanding of the underlying mechanisms causing metabolic diseases in the human subject has been obtained by absolute chemical analysis of the body fluids of which it is probably true to say that the blood ( either whole blood or serum ) has been the most extensively studied. It is becoming increasingly apparent however, that this type of approach does not offer a satisfactory explanation for the disturbed metabolic reactions in certain diseases