Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans

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dc.contributor.authorPalwende Romuald Boua
dc.contributor.authorJean-Tristan Brandenburg
dc.contributor.authorAnanyo Choudhury
dc.contributor.authorHermann Sorgho
dc.contributor.authorEngelbert A Nonterah
dc.contributor.authorGodfred Agongo
dc.contributor.authorGershim Asiki
dc.contributor.authorLisa Micklesfield
dc.contributor.authorSolomon Choma
dc.contributor.authorFrancesc Xavier Gómez-Olivé
dc.contributor.authorScott Hazelhurst
dc.contributor.authorHalidou Tinto
dc.contributor.authorNigel J Crowther
dc.contributor.authorChristopher G Mathew
dc.contributor.authorMichèle Ramsay
dc.date.accessioned2024-03-06T10:05:47Z
dc.date.available2024-03-06T10:05:47Z
dc.date.issued2022-02-14
dc.description.abstractAtherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), and FBXL17 (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, SNX29 (p = 6.3E-09), and two female-specific loci, LARP6 (p = 2.4E-09) and PROK1 (p = 1.0E-08). We replicate previous cIMT associations with different lead SNPs in linkage disequilibrium with SNPs primarily identified in European populations. Our study find significant enrichment for genes involved in oestrogen response from female-specific signals. The genes identified show biological relevance to atherosclerosis and/or CVDs, sex-differences and transferability of signals from non-African studies.
dc.description.librarianPM2023
dc.facultyFaculty of Health Sciences
dc.identifier.urihttps://hdl.handle.net/10539/37770
dc.language.isoen
dc.schoolPublic Health
dc.titleGenetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans
dc.typeArticle
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