A role for transforming growth factor alpha and its receptor in human oesophageal cancer
Loading...
Date
Authors
Jones, Gregory Justin
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A member of the epidermal growth factor (EGF) family; transforming
growth factor alpha (TGF-a) shares significant homology with EGF and
binds to the EGF receptor (EGF-R). Like EGF TGF-a plays important
roles in normal physiological processes; but, as its name signifies, it has
potent transforming ability; often associated with autocrine stimulatory
mechanisms. The purpose of this study is to investigate a possible role
for TGF-a and its receptor in certam human oesophageal squamous cell
carcinoma (SCC) cell lines - namely, WHCO-I, -3 and -5. The wellstudied
A431 epidermoid. carcinoma cell line was used throughout for
control purposes. (Abbreviation abstract)
Description
A dissertation submitted to the Faculty of Science, University of the
Witwatersrand, Johannesburg, in fulfilment of the requirements for the
degree of Master of Science.