Drug and dietary modification of platelet function
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Date
2014-12-15
Authors
Chetty, Nanthakumarn
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Abstract
A st u d y of pla t e l e c aggregation and MDA production
after an oral dose of 300mg aspirin indicated that
partial rec o v e r y of platelet function occ u r r e d when
a p p r o x i m a t e l y one third of the c i r c u lating platelets
had been rep l a c e d by new (uninhibited) platelets.
In vitro studies on mixtures of normal and aspirin
inhibited p l a t elets indicated partial restoration of
platelet agg r e g a t i o n and thromboxane production
w i t h as little as 10% of normal p l a t e l e t s in some
subjects. Re s t o r a t i o n of full function required a
higher proportion of normal platelets. There was
considerable variation between subjects. These data
suggest that complete suppression of p latelet functions
in all normal subjects r equires d a i l y a d m i n i s t r a t i o n of
the d r u g .
Despite the h y p e r a g g r e g & b i l i t y of platelets in Familial
H y p e r c h o l e s t e r o l a e m i a / ISO mg aspi r i n was shown to
inhibit p l a t e l e t aggregation to the same e.ttent as
occurs in normals.
Description
A thesis submitted to the Faculty of Medicine
University of the Witwatersr and, Johannesburg,
for the Degree of Doctor of p h ilosophy
JOHANNESBURG 1985,