Interleukin 1 production in health and disease
| dc.contributor.author | Mitchell, Renee | |
| dc.date.accessioned | 2018-06-25T08:28:52Z | |
| dc.date.available | 2018-06-25T08:28:52Z | |
| dc.date.issued | 1981 | |
| dc.description | Being a Dissertation presented in fulfilment of the requirement governing the Degree of Master of Science in The School of Medicine, University of the Witwatersrand | en_ZA |
| dc.description.abstract | Interleukin 1 (IL - 1) is a macrophage factor that exerts control over T cell activation. The experimental work presented in this dissertation consists of studies on IL - 1 production by monocytes which can be used as an in vitro correlate for monocyte function, as well as the effect of IL - 1 on immature T cells, that is, thymocytes. In accomplishing the studies presented in this dissertation, a two stage assay was employed. Firstly IL - 1 containing supernatants were produced by stimulated human peripheral blood adherent cells and secondly, the IL - 1 supernatants were assayed on mouse thymocyctes in which these supernatants caused mitogenesis. | en_ZA |
| dc.description.librarian | IT2018 | en_ZA |
| dc.identifier.uri | https://hdl.handle.net/10539/24668 | |
| dc.language.iso | en | en_ZA |
| dc.subject.mesh | Interleukin-1 | |
| dc.subject.mesh | Macrophages | |
| dc.subject.mesh | Mitogens | |
| dc.title | Interleukin 1 production in health and disease | en_ZA |
| dc.type | Thesis | en_ZA |