Building knowledge, optimising physical and mental health and setting up healthier life trajectories in South African women (Bukhali): a preconception randomised control trial part of the Healthy Life Trajectories Initiative (HeLTI)

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dc.contributor.authorShane A Norris
dc.contributor.authorCatherine E Draper
dc.contributor.authorAlessandra Prioreschi
dc.contributor.authorCM Smuts
dc.contributor.authorLisa Jayne Ware
dc.contributor.authorCindyLee Dennis
dc.contributor.authorPhilip Awadalla
dc.contributor.authorD Bassani
dc.contributor.authorZulfiqar Bhutta
dc.contributor.authorLaurent Briollais
dc.contributor.authorD William Cameron
dc.contributor.authorTobias Chirwa
dc.contributor.authorB Fallon
dc.contributor.authorCM Gray
dc.contributor.authorJill Hamilton
dc.contributor.authorJ Jamison
dc.contributor.authorHeather Jaspan
dc.contributor.authorJennifer Jenkins
dc.contributor.authorKathleen Kahn
dc.contributor.authorAP Kengne
dc.contributor.authorEstelle V Lambert
dc.contributor.authorNaomi Levitt
dc.contributor.authorMarie-Claude Martin
dc.contributor.authorMichele Ramsay
dc.contributor.authorDaniel Roth
dc.contributor.authorStephen Scherer
dc.contributor.authorDaniel Sellen
dc.contributor.authorWiedaad Slemming
dc.contributor.authorDeborah Sloboda
dc.contributor.authorM Szyf
dc.contributor.authorStephen Tollman
dc.contributor.authorMark Tomlinson
dc.contributor.authorSuzanne Tough
dc.contributor.authorStephen G Matthews
dc.contributor.authorLinda Richter
dc.contributor.authorStephen Lye
dc.date.accessioned2024-04-04T09:10:02Z
dc.date.available2024-04-04T09:10:02Z
dc.date.issued2022-03-25
dc.description.abstractis challenging due to a persistent infectious disease, burgeoning obesity, most notably among women and rising rates of non-communicable diseases (NCDs). With two thirds of women presenting at their first antenatal visit either overweight or obese in urban South Africa (SA), the preconception period is an opportunity to optimise health and offset transgenerational risk of both obesity and NCDs. Methods and analysis Bukhali is the first individual randomised controlled trial in Africa to test the efficacy of a complex continuum of care intervention and forms part of the Healthy Life Trajectories Initiative (HeLTI) consortium implementing harmonised trials in Canada, China, India and SA. Starting preconception and continuing through pregnancy, infancy and childhood, the intervention is designed to improve nutrition, physical and mental health and health behaviours of South African women to offset obesity-risk (adiposity) in their offspring. Women aged 18–28 years (n=6800) will be recruited from Soweto, an urban-poor area of Johannesburg. The primary outcome is dual-energy X-ray absorptiometry derived fat mass index (fat mass divided by height2 ) in the offspring at age 5 years. Community health workers will deliver the intervention randomly to half the cohort by providing health literacy material, dispensing a multimicronutrient supplement, providing health services and feedback, and facilitating behaviour change support sessions to optimise: (1) nutrition, (2) physical and mental health and (3) lay the foundations for healthier pregnancies and early child development. Ethics and dissemination Ethical approval has been obtained from the Human Ethics Research Committee University of the Witwatersrand, Johannesburg, South Africa (M1811111), the University of Toronto, Canada (19-0066-E) and the WHO Ethics Committee (ERC.0003328). Data and biological sample sharing policies are consistent with the governance policy of the HeLTI Consortium (https://helti.org) and South African government legislation (POPIA). The recruitment and research team will obtain informed consent.
dc.description.librarianPM2023
dc.facultyFaculty of Health Sciences
dc.identifier.urihttps://hdl.handle.net/10539/38313
dc.language.isoen
dc.schoolPublic Health
dc.titleBuilding knowledge, optimising physical and mental health and setting up healthier life trajectories in South African women (Bukhali): a preconception randomised control trial part of the Healthy Life Trajectories Initiative (HeLTI)
dc.typeArticle
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