Developing a core outcome set for hospital deprescribing trials for older people under the care of a geriatrician

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dc.contributor.authorJacqueline Martin-Kerry
dc.contributor.authorJo Taylor
dc.contributor.authorSion Scott
dc.contributor.authorMartyn Patel
dc.contributor.authorDavid Wright
dc.contributor.authorAllan Clark
dc.contributor.authorDavid Turner
dc.contributor.authorDavid Phillip Alldred
dc.contributor.authorKatherine Murphy
dc.contributor.authorVictoria Keevil
dc.contributor.authorMiles D. Witham
dc.contributor.authorIan Kellar
dc.contributor.authorDebi Bhattacharya
dc.date.accessioned2024-04-05T09:06:53Z
dc.date.available2024-04-05T09:06:53Z
dc.date.issued2022
dc.description.abstractBackground: Half of older people are prescribed unnecessary/inappropriate medications that are not routinely deprescribed in hospital hence there is a need for deprescribing trials. We aimed to develop a Core Outcome Set (COS) for deprescribing trials for older people under the care of a geriatrician during hospital admission. Methods: We developed a list of potentially relevant outcomes from the literature. Using a two-round Delphi survey of stakeholder groups representing older people and carers, hospital clinicians, hospital managers, and ageing/deprescribing researchers, each outcome was scored according to Grading of Recommendations Assessment, Development and Evaluation, followed by two consensus workshops to finalise the COS. Results: Two hundred people completed Round 1 and 114 completed Round 2. Representing all stakeholder groups, 10 people participated in workshop 1 and 10 in workshop 2. Six outcomes were identified as most important, feasible and acceptable to collect in a trial: number of prescribed medicines stopped; number of prescribed medicines with dosage reduced; quality of life; mortality; adverse drug events and number of hospital stays. Three other outcomes were identified as important, but currently too burdensome to collect: number of potentially inappropriate medicines prescribed; burden from medication routine; and medication-related admissions to hospital. Conclusions: A COS represents the minimum outcomes that should be collected and reported. Whilst uncommon practice for COS development, the value of considering outcome collection feasibility is demonstrated by the removal of three potential outcomes that, if included, may have compromised COS uptake due to challenges with collecting the data.
dc.description.librarianPM2023
dc.facultyFaculty of Health Sciences
dc.identifier.urihttps://hdl.handle.net/10539/38335
dc.language.isoen
dc.schoolPublic Health
dc.subjectdeprescribing, core outcome set, older people, hospital
dc.titleDeveloping a core outcome set for hospital deprescribing trials for older people under the care of a geriatrician
dc.typeArticle
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