Ultrasound-assisted cell eradication

Abstract

Ultrasound-based cell separation and eradication methods are advantageous because of cost-effectiveness, efficiency and its non-invasive nature. The purpose of the research was to manipulate white and red blood cells with ultrasound and force these cells to translate. This research will contribute towards an ultrasound-based method to differentiate between malaria-infected cells and healthy cells. An experimental setup was built to accommodate optical microscopy and ultrasound transducers. The ultrasound transducers located at a variable distance and angle with respect to the optical region of interest to create different ultrasound characteristics. Findings were captured with a high-speed camera. This research illustrated that when sonicated, white and red blood cells translate to the pressure nodes and pressure anti-nodes of an ultrasound field