Ultrasound-assisted cell eradication
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Date
2020
Authors
Smalberger, Charl
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Abstract
Ultrasound-based cell separation and eradication methods are advantageous because of cost-effectiveness, efficiency and its non-invasive nature. The purpose of the research was to manipulate white and red blood cells with ultrasound and force these cells to translate. This research will contribute towards an ultrasound-based method to differentiate between malaria-infected cells and healthy cells. An experimental setup was built to accommodate optical microscopy and ultrasound transducers. The ultrasound transducers located at a variable distance and angle with respect to the optical region of interest to create different ultrasound characteristics. Findings were captured with a high-speed camera. This research illustrated that when sonicated, white and red blood cells translate to the pressure nodes and pressure anti-nodes of an ultrasound field
Description
A dissertation submitted to the Faculty of Engineering and the Built Environment, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Engineering, 2020