Antiretroviral Drug Use and HIV Drug Resistance Among Young Women in Rural South Africa: HPTN 068

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dc.contributor.authorZhang, Yinfeng PhD
dc.contributor.authorSivay, Mariya V. PhD
dc.contributor.authorHudelson, Sarah E. BS
dc.contributor.authorClarke, William PhD
dc.contributor.authorBreaud, Autumn MS
dc.contributor.authorWang, Jing MS, MA
dc.contributor.authorPiwowar-Manning, Estelle BS, MT (ASCP)
dc.contributor.authorAgyei, Yaw MPH, BS, MT (ASCP)
dc.contributor.authorFogel, Jessica M. PhD
dc.contributor.authorHamilton, Erica L. MPH
dc.contributor.authorSelin, Amanda MHS
dc.contributor.authorMacPhail, Catherine PhD
dc.contributor.authorKahn, Kathleen MD, PhD
dc.contributor.authorGómez-Olivé, Francesc Xavier MD, PhD
dc.contributor.authorHughes, James P. PhD
dc.contributor.authorPettifor, Audrey PhD, MPH
dc.contributor.authorEshleman, Susan H. MD, PhD
dc.date.accessioned2023-09-12T10:42:16Z
dc.date.available2023-09-12T10:42:16Z
dc.date.issued2018-11-01
dc.departmentSA-MRC/Wits Agincourt UnitE
dc.description.abstractBackground: Antiretroviral (ARV) drugs are used for HIV treatment and prevention. We analyzed ARV drug use and HIV drug resistance in a cohort of young women in rural South Africa enrolled in the HIV Prevention Trials Network (HPTN) 068 study, which evaluated the use of a cash transfer conditional on school attendance to reduce HIV incidence. Methods: ARV drug testing was performed using plasma samples from 2526 young women. This included 2526 enrollment samples (80 HIV-infected and 2446 HIV-uninfected) and 162 seroconversion samples (first HIV-positive study visit). Testing was performed using a qualitative assay that detects 20 ARV drugs from 5 drug classes. HIV drug resistance testing was performed with the ViroSeq HIV-1 Genotyping System for samples that had HIV viral loads ≥400 copies per milliliter. Results: At enrollment, ARV drugs were detected in 10 (12.5%) of 80 HIV-infected young women. None of 2446 HIV-uninfected young women had ARV drugs detected at enrollment. ARV drugs were also detected in 16 (9.9%) of 162 seroconverters. At enrollment, 9 (13.4%) of 67 young women with genotyping results had HIV drug resistance; resistance was also detected in 9 (6.9%) of 131 seroconverters with genotyping results. Conclusions: Most of the HIV-infected young women in this cohort from rural South Africa were not taking ARV drugs, suggesting they were unaware of their HIV status or were not in care. HIV drug resistance was detected in young women with both prevalent and new HIV infection.
dc.description.librarianPM2023
dc.identifier.urihttp://hdl.handle.net/10539/35878
dc.language.isoen
dc.schoolPublic HelathE
dc.titleAntiretroviral Drug Use and HIV Drug Resistance Among Young Women in Rural South Africa: HPTN 068
dc.typeArticle
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