Coronavirus Host Genomics Study: South Africa (COVIGen-SA)

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dc.contributor.authorAndrew K. May
dc.contributor.authorHeather Seymour
dc.contributor.authorHarriet Etheredge
dc.contributor.authorHeather Maher
dc.contributor.authorMarta C. Nunes
dc.contributor.authorShabirA.Madhi
dc.contributor.authorSimisoM. Sokhela
dc.contributor.authorW. D. FrancoisVenter
dc.contributor.authorNeil Martinson
dc.contributor.authorFirdaus Nabeemeeah
dc.contributor.authorCheryl Cohen
dc.contributor.authorJocelyn Moyes
dc.contributor.authorSibongile Walaza
dc.contributor.authorStefano Tempia
dc.contributor.authorJackie Kleynhans
dc.contributor.authorAnne von Gottberg
dc.contributor.authorJeremy Nel
dc.contributor.authorHalima Dawood
dc.contributor.authorEbrahim Variava
dc.contributor.authorStephen Tollman
dc.contributor.authorKathleen Kahn
dc.contributor.authorKobusHerbst
dc.contributor.authorEmilyB.Wong
dc.contributor.authorCarolineT.Tiemessen
dc.contributor.authorAlex van Blydenstein
dc.contributor.authorLyle Murray
dc.contributor.authorMichelle Venter
dc.contributor.authorJune Fabian
dc.contributor.authorMiche´le Ramsay
dc.date.accessioned2024-04-05T08:59:22Z
dc.date.available2024-04-05T08:59:22Z
dc.date.issued2022-10-06
dc.description.abstractHowever, continental Africans are yet to be adequately represented in such studies despite the importance of genetic factors in understanding Africa’s response to the pandemic. We describe the development of a research resource for coronavirus host genomics studies in South Africa known as COVIGen-SA—a multicollaborator strategic partnership designed to provide harmonised demographic, clinical, and genetic information specific to Black South Africans with COVID-19. Over 2,000 participants have been recruited to date. Preliminary results on 1,354 SARS-CoV-2 positive participants from four participating studies showed that 64.7% were female, 333 had severe disease, and 329 were people living with HIV. *rough this resource, we aim to provide insights into host genetic factors relevant to African-ancestry populations, using both genome-wide association testing and targeted sequencing of important genomic loci. *is project will promote and enhance partnerships, build skills, and develop resources needed to address the COVID-19 burden and associated risk factors in South African communities.
dc.description.librarianPM2023
dc.facultyFaculty of Health Sciences
dc.identifier.urihttps://hdl.handle.net/10539/38333
dc.language.isoen
dc.schoolPublic Health
dc.titleCoronavirus Host Genomics Study: South Africa (COVIGen-SA)
dc.typeArticle
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