An investigation of p-glycoprotein in plasmodium falciparum and the isolation of haemozoin
| dc.contributor.author | De Almeida, Maria, Rosario | |
| dc.date.accessioned | 2018-10-02T12:30:34Z | |
| dc.date.available | 2018-10-02T12:30:34Z | |
| dc.date.issued | 1992 | |
| dc.description | A dissertation submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg For the degree of Master of Science in Medicine | en_ZA |
| dc.description.abstract | Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptical parasites, and this is thought to be the basis of their resistance ( Fitch, 1970 ). Martin et. al ( 1987 ), recently demonstrated that in the presence of verapamil, a calcium channel blocker, chloroquine-resistant P falciparum becomes chloroquine-sensitive, with an increase in the chloroquine accumulation.The mechanism of such reversal has yet to be elucidated | en_ZA |
| dc.description.librarian | IT2018 | en_ZA |
| dc.identifier.uri | https://hdl.handle.net/10539/25712 | |
| dc.language.iso | en | en_ZA |
| dc.subject | hemozoin | |
| dc.subject.mesh | Plasmodium | |
| dc.subject.mesh | Plasmodium falciparum | |
| dc.subject.mesh | ATP-Binding Cassette, Sub-Family B, Member 1 | |
| dc.title | An investigation of p-glycoprotein in plasmodium falciparum and the isolation of haemozoin | en_ZA |
| dc.type | Thesis | en_ZA |
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