An investigation of p-glycoprotein in plasmodium falciparum and the isolation of haemozoin
Loading...
Date
Authors
De Almeida, Maria, Rosario
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptical parasites, and this is thought to be the basis of their resistance ( Fitch, 1970 ). Martin et. al ( 1987 ), recently demonstrated that in the presence of verapamil, a calcium channel blocker, chloroquine-resistant P falciparum becomes chloroquine-sensitive, with an increase in the chloroquine accumulation.The mechanism of such reversal has yet to be elucidated
Description
A dissertation submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg
For the degree of Master of Science in Medicine