Genome-wide association study of population-standardised cognitive performance phenotypes in a rural South African community.

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dc.contributor.authorCassandra C. Soo
dc.contributor.authorJean-Tristan Brandenburg
dc.contributor.authorAlmut Nebel
dc.contributor.authorStephen Tollman
dc.contributor.authorLisa Berkman
dc.contributor.authorMichèle Ramsay
dc.contributor.authorAnanyo Choudhury
dc.date.accessioned2024-03-04T10:25:44Z
dc.date.available2024-03-04T10:25:44Z
dc.date.issued2023-03-27
dc.description.abstractCognitive function is an indicator for global physical and mental health, and cognitive impairment has been associated with poorer life outcomes and earlier mortality. A standard cognition test, adapted to a rural-dwelling African community, and the Oxford Cognition Screen-Plus were used to capture cognitive performance as five continuous traits (total cognition score, verbal episodic memory, executive function, language, and visuospatial ability) for 2,246 adults in this population of South Africans. A novel common variant, rs73485231, reached genome-wide significance for association with episodic memory using data for ~14 million markers imputed from the H3Africa genotyping array data. Windowbased replication of previously implicated variants and regions of interest support the discovery of African-specific associated variants despite the small population size and low allele frequency. This African genome-wide association study identifies suggestive associations with general cognition and domain-specific cognitive pathways and lays the groundwork for further genomic studies on cognition in Africa.
dc.description.librarianPM2023
dc.facultyFaculty of Health Sciences
dc.identifier.urihttps://hdl.handle.net/10539/37749
dc.language.isoen
dc.schoolPublic Health
dc.titleGenome-wide association study of population-standardised cognitive performance phenotypes in a rural South African community.
dc.typeArticle
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