Human respiratory syncytial virus diversity and epidemiology among patients hospitalized with severe respiratory illness in South Africa, 2012–2015

Simple item page
dc.contributor.authorZiyaad Valley-Omar
dc.contributor.authorStefano Tempia
dc.contributor.authorOrienka Hellferscee
dc.contributor.authorSibongile Walaza
dc.contributor.authorEbrahim Variava6
dc.contributor.authorHalima Dawood
dc.contributor.authorKathleen Kahn
dc.contributor.authorMeredith McMorrow
dc.contributor.authorMarthi Pretorius
dc.contributor.authorSenzo Mtshali
dc.contributor.authorErnest Mamorobela
dc.contributor.authorNicole Wolter
dc.contributor.authorMarietjie Venter
dc.contributor.authorAnne von Gottberg
dc.contributor.authorCheryl Cohen
dc.contributor.authorFlorette K. Treurnicht
dc.date.accessioned2024-05-16T10:29:15Z
dc.date.available2024-05-16T10:29:15Z
dc.date.issued2015
dc.description.abstractBackground: We aimed to describe the prevalence of human respiratory syncytial virus (HRSV) and evaluate associations between HRSV subgroups and/or genotypes and epidemiologic characteristics and clinical outcomes in patients hospitalized with severe respiratory illness (SRI). Methods: Between January 2012 and December 2015, we enrolled patients of all ages admitted to two South African hospitals with SRI in prospective hospital-based syndromic surveillance. We collected respiratory specimens and clinical and epidemiological data. Unconditional random effect multivariable logistic regression was used to assess factors associated with HRSV infection. Results: HRSV was detected in 11.2% (772/6908) of enrolled patients of which 47.0% (363/772) were under the age of 6 months. There were no differences in clinical outcomes of HRSV subgroup A-infected patients compared with HRSV subgroup B-infected patients but among patients aged <5 years, children with HRSV subgroup A were more likely be coinfected with Streptococcus pneumoniae (23/208 11.0% vs. 2/90, 2.0%; adjusted odds ratio 5.7). No significant associations of HRSV A genotypes NA1 and ON1 with specific clinical outcomes were observed. Conclusions: While HRSV subgroup and genotype dominance shifted between seasons, we showed similar genotype diversity as noted worldwide. We found no association between clinical outcomes and HRSV subgroups or genotypes.
dc.description.librarianPM2023
dc.facultyFaculty of Health Sciences
dc.identifier.urihttps://hdl.handle.net/10539/38479
dc.language.isoen
dc.schoolPublic Health
dc.subjecthuman respiratory syncytial virus, severe respiratory illness, South Africa
dc.titleHuman respiratory syncytial virus diversity and epidemiology among patients hospitalized with severe respiratory illness in South Africa, 2012–2015
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IRV-16-222.pdf
Size:
1.57 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.43 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
SA-MRC/Wits Agincourt Unit (Research Outputs/Publications)