In vitro Evaluation of Porous borosilicate, borophosphate and phosphate Bioactive Glasses Scaffolds fabricated using Foaming Agent for Bone Regeneration

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dc.contributor.authorErasmus, E. P.
dc.contributor.authorSule, R.
dc.contributor.authorJohnson, O. T.
dc.contributor.authorMassera, J.
dc.contributor.authorSigalas, I.
dc.date.accessioned2024-10-07T07:48:51Z
dc.date.available2024-10-07T07:48:51Z
dc.date.issued2018
dc.description.abstractIn this work, glasses within the borosilicate borophosphate and phosphate family were sintered into 3D porous scaffolds using 60 and 70 vol. % NH4(HCO3) as a foaming agent. All scaffolds produced remained amorphous; apart from one third of the glasses which crystallized. All produced scaffolds had porosity >50% and interconnected pores in the range of 250–570 μm; as evidenced by μCT. The in-vitro dissolution of the scaffolds in SBF and changes in compression were assessed as a function of immersion time. The pH of the solution containing the borosilicate scaffolds increased due to the typical noncongruent dissolution of this glass family. Borophosphate and phosphate scaffolds induced a decrease in pH upon dissolution attributed to the congruent dissolution of those materials and the large release of phosphate within the media. As prepared, scaffolds showed compressive strength of 1.29 ± 0.21, 1.56 ± 0.63, 3.63 ± 0.69 MPa for the borosilicate, borophosphate and phosphate samples sintered with 60 vol. % NH4 (HCO3), respectively. Evidence of hydroxyapatite precipitation on the borosilicate glass scaffolds was shown by SEM/EDS, XRD and ICP-OES analysis. The borophosphate scaffolds remained stable upon dissolution. The phosphate scaffolds were fully crystallized, leading to very large release of phosphate in the media.
dc.description.submitterPM2024
dc.facultyFaculty of Engineering and the Built Environment
dc.identifier.citationErasmus, E.P., Sule, R., Johnson, O.T. et al. In vitro Evaluation of Porous borosilicate, borophosphate and phosphate Bioactive Glasses Scaffolds fabricated using Foaming Agent for Bone Regeneration. Sci Rep 8, 3699 (2018). https://doi.org/10.1038/s41598-018-22032-2
dc.identifier.issn2045-2322 (Online)
dc.identifier.other10.1038/s41598-018-22032-2
dc.identifier.urihttps://hdl.handle.net/10539/41390
dc.journal.titleScientific Reports
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofseriesVol. 8; a3699
dc.rights© The Author(s). 2018 Open Access, This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
dc.schoolSchool of Chemical and Metallurgical Engineering
dc.subjectBioinspired materials
dc.subjectOrthopaedics
dc.subject.otherSDG-17: Partnerships for the goals
dc.titleIn vitro Evaluation of Porous borosilicate, borophosphate and phosphate Bioactive Glasses Scaffolds fabricated using Foaming Agent for Bone Regeneration
dc.typeArticle
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