The Effect of PrEP Use Disclosure on Adherence in a Cohort of Adolescent Girls and Young Women in South Africa

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dc.contributor.authorDanielle Giovenco
dc.contributor.authorAudrey Pettifor
dc.contributor.authorKimberly A Powers
dc.contributor.authorLisa Hightow-Weidman
dc.contributor.authorBrian W Pence
dc.contributor.authorJessie K Edwards
dc.contributor.authorKatherine Gill
dc.contributor.authorJennifer F Morton
dc.contributor.authorAriane van der Straten
dc.contributor.authorConnie Celum
dc.contributor.authorLinda-Gail Bekker
dc.date.accessioned2024-04-01T17:59:19Z
dc.date.available2024-04-01T17:59:19Z
dc.date.issued2022-04
dc.description.abstractEffective strategies to support PrEP adherence among adolescent girls and young women (AGYW) are needed. We examined PrEP use disclosure and its effect on adherence among 200 AGYW ages 16-25 initiating PrEP in South Africa to help inform these strategies. We estimated the relative prevalence of high adherence (intracellular tenofovir-diphosphate concentration ≥ 700 fmol/punch) 3- and 6-months after PrEP initiation among those who disclosed vs. did not disclose their PrEP use, both overall and by age. Most AGYW disclosed to a parent (58%), partner (58%), or friend (81%) by month 6. We did not observe a strong effect of disclosure on adherence overall; however, among younger AGYW (≤ 18 years), those who disclosed to a parent were 6.8 times as likely to have high adherence at month 6 than those who did not (95% CI 1.02, 45.56). More work is needed to understand parents' roles as allies and identify ways peers and partners can motivate PrEP use for AGYW.
dc.description.librarianPM2023
dc.facultyFaculty of Health Sciences
dc.identifier.urihttps://hdl.handle.net/10539/38256
dc.language.isoen
dc.schoolPublic Health
dc.subjectAdolescent girls and young women; Disclosure; HIV prevention; PrEP; Pre-exposure prophylaxis.
dc.titleThe Effect of PrEP Use Disclosure on Adherence in a Cohort of Adolescent Girls and Young Women in South Africa
dc.typeArticle
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