Globin genes of the South African Indian population group.
Date
1994
Authors
Krause, Amanda
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Abstract
Most South Africans with clinically significant haemoglobinopathies, mainly thalassaemia
major, are of Asian Indian origin. This study was undertaken to characterise the normal
and pathological variation around the a and B globin clusters, both at the haematological
and molecular level in the major religious and language subgroups of South African
Indians, These data were used to assess the need for a screening programme for the major
haemoglobinopathies and to evaluate the local prenatal diagnostic service. The variation
was also used to assess the genetic relationships between the subgroups of South African
Indians, to compare them to Indians studied elsewhere and to other populations. (Abbreviation abstract)
Description
A dissertation submitted to the Faculty of Medicine, University of tlie Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Doctor of Pliilosophy
Keywords
Hemaglobinopathies.