Human papillomavirus genotypes in invasive cervical carcinoma in HIV-seropositive and HIV-seronegative women in Zimbabwe
Date
2020
Authors
Mudini, Washington
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Abstract
Invasive cervical carcinoma (ICC) accounts for 23% of all
cancer-related deaths in Zimbabwean women. Trials for a national program of
genotype-specific HPV vaccinesare underway to prevent cervical carcinoma, but
the distribution of HPV types among women with ICC according to HIV status is
unknown.
METHODS—To determine prevalence and distribution of high-risk HPV
genotypes by HIVstatus in women with ICC, we performed a cross-sectional study
on women referred for ICC testing at four urban referral hospitals in Zimbabwe
from June 2014 - December 2015. Cervical biopsies were obtained for histology
and HPV genotyping. HIV serology testing was performed. HPV testing was
performed using MY09/MY11 PCR followed by typing using dot blot
hybridization.
RESULTS—Of 107 participants with histologically-proven, HIV prevalence was
49.5% (53/107). HIV-positive women tended to be younger (median age 44 years)
than HIV-negative women.
Description
A research submitted in fulfilment for the degree of Masters in Medicine (MMED) Anatomical Pathology to the Faculty of Health Sciences, School of Clinical Medicine University of the Witwatersrand, Johannesburg, 2020