Human papillomavirus genotypes in invasive cervical carcinoma in HIV-seropositive and HIV-seronegative women in Zimbabwe
| dc.contributor.author | Mudini, Washington | |
| dc.date.accessioned | 2020-11-03T14:11:41Z | |
| dc.date.available | 2020-11-03T14:11:41Z | |
| dc.date.issued | 2020 | |
| dc.description | A research submitted in fulfilment for the degree of Masters in Medicine (MMED) Anatomical Pathology to the Faculty of Health Sciences, School of Clinical Medicine University of the Witwatersrand, Johannesburg, 2020 | en_ZA |
| dc.description.abstract | Invasive cervical carcinoma (ICC) accounts for 23% of all cancer-related deaths in Zimbabwean women. Trials for a national program of genotype-specific HPV vaccinesare underway to prevent cervical carcinoma, but the distribution of HPV types among women with ICC according to HIV status is unknown. METHODS—To determine prevalence and distribution of high-risk HPV genotypes by HIVstatus in women with ICC, we performed a cross-sectional study on women referred for ICC testing at four urban referral hospitals in Zimbabwe from June 2014 - December 2015. Cervical biopsies were obtained for histology and HPV genotyping. HIV serology testing was performed. HPV testing was performed using MY09/MY11 PCR followed by typing using dot blot hybridization. RESULTS—Of 107 participants with histologically-proven, HIV prevalence was 49.5% (53/107). HIV-positive women tended to be younger (median age 44 years) than HIV-negative women. | en_ZA |
| dc.description.librarian | TL (2020) | en_ZA |
| dc.faculty | Faculty of Health Sciences | en_ZA |
| dc.identifier.uri | https://hdl.handle.net/10539/29936 | |
| dc.language.iso | en | en_ZA |
| dc.title | Human papillomavirus genotypes in invasive cervical carcinoma in HIV-seropositive and HIV-seronegative women in Zimbabwe | en_ZA |
| dc.type | Thesis | en_ZA |