3. Electronic Theses and Dissertations (ETDs) - All submissions

Permanent URI for this communityhttps://wiredspace.wits.ac.za/handle/10539/45

Browse

Subject: search.filters.subject.Neutrophils

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Comparison of vaccine and wild- type measles virus strains effect on polymorphonuclear leukocyte function : an in vitro analysis.
    (2001-08-31) Phungwayo., Mokete. Amos. Nehemia
    Measles virus (MV)-infected persons have been found to be at a greatly increased risk of developing respiratory infections caused mainly by Staphylococcus aureus and Mycobacterium tuberculosis. Secondary microbial infections have been implicated as important causes of morbidity and mortality in patients with measles. Polymorphonuclear leukocytes (PMNL), the first cells of the immune system to migrate to the site of microbial invasion, are the principal cells involved in the immune response to invasion of the host by microbes, particularly bacteria and fungi.
  • No Thumbnail Available
    Item
    Investigation of the immune-modulatory effects of erythromycin
    (1986-06-20) Fernandes, Antonio, Celestino
    The Literature Review covers the immunosuppressive and immunopotentiating properties of antibiotics on the immune system and the effects these could have on the resolution of an infection. The possible pathogenic mechanisms of C. albicans are also reviewed in this section. The experimental section shows that pre-treatment of mice with erythromycin increases the mean survival time following intraperitoneal inoculation of C. albicans. It was shown that erythromycin enhanced lymphocyte transformation and PMNL migration in both in-vivo and in-vitro situations. These enhanced immunological components probably caused improved survival times in the aforementioned animal experiments. To investigate the effects of oral administration of erythromycin on in-vivo PMNL migration in adult volunteers a new quantitative test which could only be applied to humans was developed and is described in detail. Using this method preliminary data were obtained which show that erythromycin increases PMNL migration in-vivo.
  • No Thumbnail Available
    Item
    The relationship between neutrophil reactive oxidant production, lung function and anti-oxidant nutrients
    (1991-05-21) Richards, Guy, Antony
    This thesis describes and discusses oxidants and anti-oxidants and their relation to human disease. Cigarette smoking is used as the model for the study of chronic inflammatory processes, firstly, to establish a causative link between oxidants and disease viz. lung function abnormalities in smokers, secondly to evaluate the interaction between hyperactive phagocytes and anti-oxidant defences and thirdly, to investigate the possibility that intervention with anti-oxidants may ameliorate the effects of chronic inflammation.
Copyright Ownership Is Guided By The University's

Intellectual Property policy

Students submitting a Thesis or Dissertation must be aware of current copyright issues. Both for the protection of your original work as well as the protection of another's copyrighted work, you should follow all current copyright law.