The relationship between neutrophil reactive oxidant production, lung function and anti-oxidant nutrients
Richards, Guy, Antony
This thesis describes and discusses oxidants and anti-oxidants and their relation to human disease. Cigarette smoking is used as the model for the study of chronic inflammatory processes, firstly, to establish a causative link between oxidants and disease viz. lung function abnormalities in smokers, secondly to evaluate the interaction between hyperactive phagocytes and anti-oxidant defences and thirdly, to investigate the possibility that intervention with anti-oxidants may ameliorate the effects of chronic inflammation.
A dissertation submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg. in fulfilment of the requirements for the degree of Doctor of Philosophy