3. Electronic Theses and Dissertations (ETDs) - All submissions
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Item Lysogeny in encapsulated and nontypable strains of haemophilus influenzae(1991) Muthivhi., TshlidziLimited information on the prevalence of lysogeny and the morphological features of bacteriophages in encapsulated and nontypable strains of Haemophilus influenzae is available from the literature. This study was conducted to investigate lysogeny in wild-type strains of H. influenzae and to characterize bacteriophages recovered from these clinical strains. Following induction by mitomycin C, 16 of 58 isolates of H. influenzae tested produced lysis. Addition of chloramphenicol inhibited cell lysis, indicating that protein synthesis was essential for induction. Type b capsules did not inhibit cell lysis or their ability to become lysoginizedItem A randomised trial of the safety and immunogenicity of low dose haemophilus conjugate vaccine in healthy infants at 6,10, and 14 weeks of age(2002-09-01) Nicol, Mark. Patrick.Background Despite their proven efficacy, Haemophilus influenzae type b (Hib) conjugate vaccines are not given to most children in the developing world in the face of an estimated global Hib disease burden of nearly 2 million cases per annum. A major barrier to the introduction of the vaccine would be overcome by diluting the vaccine tenfold in DTP. We report a randomised trial comparing the use of Hib conjugate vaccine diluted tenfold in a multidose vial of DTP, with that of the full Hib dose.Item The impact of haemophilus influenzae type b (hib) vaccine on pneumonia and meningitis among children under the age of 1 year in the Klerksdorp district of the North West Province(2000-11-07) Sebekedi ( Nee Mhele), Otsile, CalviniaThe purpose of this study was to determine the impact of Hib vaccine on pneumonia and meningitis in children under the age of 1 year in the Klerksdorp district of the North West Province.Item Trends and factors associated with invasive non-typeable and serotype B Haemophilus influenzae disease in persons of all ages in South Africa from 2003-2009(2013-04) Fortuin-de Smidt, Melony CathlinHaemophilus influenzae type b disease (Hib) was a major cause of childhood disease but has nearly been eliminated in developed countries after the introduction of Hib conjugate vaccine. An increase in non-typeable H. influenzae (NTHi) disease was observed in some countries post-Hib vaccination which prompted concerns about possible serotype replacement. Hib disease in children <5 years of age decreased by a minimum estimate of 71% in South Africa after the Hib vaccine introduction in 1999. The epidemiology of Hib disease among persons >5 year olds and NTHi disease in all ages has not been described in South Africa before. The aim of this study is therefore to describe the trends and factors associated with invasive Hib and NTHi disease in South Africa, 2003-2009 among persons of all ages.