A randomised trial of the safety and immunogenicity of low dose haemophilus conjugate vaccine in healthy infants at 6,10, and 14 weeks of age
Nicol, Mark. Patrick.
Background Despite their proven efficacy, Haemophilus influenzae type b (Hib) conjugate vaccines are not given to most children in the developing world in the face of an estimated global Hib disease burden of nearly 2 million cases per annum. A major barrier to the introduction of the vaccine would be overcome by diluting the vaccine tenfold in DTP. We report a randomised trial comparing the use of Hib conjugate vaccine diluted tenfold in a multidose vial of DTP, with that of the full Hib dose.
A Research Report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Medicine in the branch of Medical Microbiology