Research Outputs (Oral Health Sciences)
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Item Cemento-enamel junction variability within the mouth(1988) Grossman, E. S.; Hargreaves, J. A.Item Base solubility and marginal sealing in amalgam restored teeth(1991) Grossman, E. S.; Witcomb, M. J.; Matejka, J. M.Item Social class and dental caries in 11-12-year-old South African schoolchildren(1989) Cleaton-Jones, P.; Hargreaves, J. A.; Williams, S. D. L.; et al.The objective of this study was to examine effects of social class on dental caries in five African populations. Definitions of social class that could be used for the different ethnic groups are outlined. A total of 1 154 children from rural black, urban black, urban Indian, urban coloured and urban white groups were clinically examined and classified into social class by parental occupations. Within group comparisons showed no statistically significant differences in DMFT or DMFS scores by social class. Comparison of the urban white children to a similar group in South Wales showed slightly lower caries in South African children of similar social class. The complexity of the different ethnic groups in South Africa, in respect of social classification, is difficult to assess for comparison with social systems in developed countries. It is recommended that an appropriate social classification be developed for South Africa ’s developed/developing population mixture. Also as we enter the 1990’s sound baseline caries data need to be collected for longitudinal evaluation of changes in the disease patternItem Systematic review of factors influencing oral healthrelated quality of life in children in Africa(2019-07-24) Kolisa Y; Yengopal V; Igumbor J; Nqcobo CBackground: Oral health-related quality of life (OHRQoL) is influenced by cultural and societal context. Existing OHRQoL children measurement tools have been conceptualised in high-income countries. Probing whether the factors influencing OHRQoL are context-reliant in the African setting is necessary and is the purpose of the current review. Aim: To investigate if the factors influencing OHRQoL are context-reliant. Methods: Seven databases were searched using search terms (‘oral health’; and ‘quality of life’, ‘health-related quality of life’, ‘patient-reported outcomes’, ‘well-being’; and ‘child*’, ‘adolescents’, ‘teen*’, ‘youth’; and ‘determinants’, ‘factors’, ‘predictors’; and ‘oral health quality of life tools/instruments/scales’; and ‘Africa*’). Abstracts identified were exported to a reference software manager. Three of the authors used specific selection criteria to review, firstly, 307 abstracts and, secondly, 30 full papers. Data were extracted from these papers using a pre-designed data extraction form, after which quantitative synthesis of data was performed. Results: Key factors influencing OHRQoL followed an existing conceptual framework where environmental and individual factors in the form of socio-economic status (SES), area of residence and children psyche status, and the presence of any oral condition other than dental caries were reported among child populations in Africa. Conclusion: There is preliminary evidence to suggest an association between individual factors such as children’s psyche and oral problems, excluding dental caries, and environmental determinants such as area of residence and SES in children’s OHRQoL in African children. The finding that dental caries was not a key factor in child-oral health is unexpected. There seemed to be a contextual viewpoint underpinning the current OHRQoL frameworks and OHRQoL was context-reliant.Item Depth and area of dental erosions, and dental caries, in bulimic women(Sage Pub, 1989) Jones, R. R. H.; Cleaton-Jones, P.Dental caries and the severity (depth) and area of erosions of tooth substance were studied in 11 bulimic subjects and 22 matched controls. Erosions were seen in 69% of the bulimics' teeth and in only 7% of the controls' (p less than 0.001). Depth of penetration was greater in the bulimics, extending even into the pulp, and the area of erosion was also larger. Scores for dental caries were higher in bulimics (mean DMFS 27.9, median 36) than in controls (mean DMFS 19.1, median 13.5), although the difference was not statistically significant. This study suggests that when erosions are present on the lingual surfaces of maxillary anterior teeth, as well as on the buccal surfaces of maxillary canines, premolars, and maxillary incisors, a diagnosis of bulimia is likely. Patients with these signs should be referred for medical help.Item Zinc oxide-eugenol and calcium hydroxide pulpectomies in baboon primary molars: histological responses(2004) Cleaton-Jones, P.; Duggal, M.; Parak, R.; et alAIM: To compare histological responses to zinc oxide-eugenol (ZOE) and calcium hydroxide (CH) pulpectomies in primary molar teeth with inflamed pulps. STUDY DESIGN:This was an experimental study in 17 juvenile baboons (Papio ursinus). METHODS: Pulpitis was induced with fresh human carious dentine or Streptococcus mutans placed into occlusal cavities in 78 primary molars; after 14 days a pulpectomy was performed on the same primary molars with the two root fillings randomly allocated. The root canal openings were then covered with IRM and the cavity filled with amalgam. After 90 days specimens were harvested and examined under the light microscope with the examiner blind to the treatment. RESULTS:Reaction frequencies in the ZOE-treated versus CH-treated teeth were: no recognisable pulp 89% and 82%, internal root resorption 0% and 1%, external root resorption 11% and 24%, presence of bacteria 5% and 18%, periapical abscesses 24% and 52%. STATISTICS:Fisher's exact probability test showed a statistically significant higher prevalence of periapical abscesses in the CH-treated group (P=0.03, relative risk 2.2). CONCLUSIONS: ZOE pulpectomy is preferred to CH for the treatment of infected pulps in primary molarsItem Hypocalcification and hypoplasia in primary teeth of pre-school children from different ethnic groups in South Africa(1989) Hargreaves, J. A.; Cleaton-Jones, P. E.; Roberts, G. J.; Et alA study was completed in 1985/86 which examined the dental health of pre-school children from different ethnic groups and communities in South Africa: rural black, urban black, urban colored, urban Indian, and urban white. Enamel defects were recorded in primary teeth by use of the HHI, an index developed to measure hypocalcification and hypoplasia of enamel. The findings showed that colored children had the greatest number of enamel defects. The teeth most commonly affected were the maxillary anterior teeth and mandibular molar teeth. It is suggested that further epidemiological studies utilizing the HHI should be undertaken in pre-school children, especially from developing countries, to gain more information on the causes of enamel defects in the primary dentition and the possible use of such findings to predict nutritional health of individuals.Item Ferric sulphate and formocresol pulpotomies in baboon primary molars: histological responses(2002) Cleaton-Jones, P.; Duggal, M.; Parak, R.; Et alAim: To compare pulpal reactions to ferric sulphate and formocresol pulpotomies in primary molar teeth with inflamed pulps. Study design: An experimental study in 15 juvenile baboons (Papio ursinus). Materials and methods: Pulpitis was induced with fresh human carious dentine or Streptococcus mutans placed into occlusal cavities in 57 primary molars; after 14 days a pulpotomy was performed on the same primary molars with the two pulp medicaments randomly allocated; the pulp was covered with IRM and the cavity filled with amalgam. After 90 days specimens were harvested and examined under the light microscope with the examiner blind to the treatment. Results: Reaction frequencies in the ferric sulphate-treated and formocresol-treated teeth were: recognisable pulp 52% and 50%, dentine bridges 16% and 12%, internal root resorption 12% and 4%, external resorption 28% and 31%, bacteria 12% and 23%, peri-apical abscesses 32% and 38%. Statistics: Fisher’s exact probability test showed no statistically significant differences between reaction frequencies in the two treatment groups. Conclusion: A pulpotomy in a primary tooth may be clinically successful in the presence of adverse histological reactions.Item Hypocalcification and hypoplasia in permanent teeth of children from different ethnic groups in South Africa assessed with a new index(1989) Hargreaves, J. A.; Cleaton-Jones, P. E.; Williams, S. D. L.A new descriptive index, the HHI (hypocalcification-hypoplasia index), is described for comparing enamel defects in groups of people. The index was used in a study completed in 1986, in which 1251 11-year-old children from different ethnic groups resident in South Africa were examined: 210 rural black, 203 urban black, 206 urban colored, 426 urban Indian, and 206 urban white. The index can be used as a screening examination, and the results from these different ethnic groups are presented.Item Growth and morphogenetic factors in bone induction: role of osteogenin and related bone morphogenetic proteins in craniofacial and periodontal bone repair.(1992) Ripamonti, Ugo; Reddi, A. H.Bone has considerable potential for repair as illustrated by the phenomenon of fracture healing. Repair and regeneration of bone recapitulate the sequential stages of development. It is well known that demineralized bone matrix has the potential to induce new bone formation locally at a heterotopic site of implantation. The sequential development of bone is reminiscent of endochondral bone differentiation during bone development. The collagenous matrix-induced bone formation is a prototype model for matrix-cell interactions in vivo. The developmental cascade includes migration of progenitor cells by chemotaxis, attachment of cells through fibronectin, proliferation of mesenchymal cells, and differentiation of bone. The bone inductive protein, osteogenin, was isolated by heparin affinity chromatography. Osteogenin initiates new bone formation and is promoted by other growth factors. Recently, the genes for osteogenin and related bone morphogenetic proteins were cloned and expressed. Recombinant osteogenin is osteogenic in vivo. The future prospects for bone induction are bright, and this is an exciting frontier with applications in oral and orthopaedic surgery.