Nephrology

Permanent URI for this collectionhttps://wiredspace.wits.ac.za/handle/10539/32807

This collection contains data collected in the course of clinical work in Nephrology across several hospitals In particular , the CMJAH Living Donor Clinic has a long history . You can see that the work of the unit has inspired or directly produced many thesis. We also have a selection of work on transplants. This collection also includes data on kidney disease from other tertiary hospitals in gauteng

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PARTICIPANT NOTICE OF DATA SHARING FOR STUDY TITLED ‘EVALUATION OF POTENTIAL KIDNEY DONORS AND OUTCOMES POST-DONATION AT CHARLOTTE MAXEKE JOHANNESBURG ACADEMIC HOSPITAL (1983-2015)’.

Good day, The Division of Nephrology at Charlotte Maxeke Johannesburg Academic Hospital ( Previously JHB GEN)conducted a research study in the unit’s Living Donor Clinic. The study assessed clinical data of all individuals who presented to this clinic from January 1983 to July 2015. Written permission to access clinical records was obtained from the Human Research Ethics Committee (Medical) of the University of the Witwatersrand, Johannesburg. The purpose of the study was to analyze living kidney donation in the South African setting with the hope that the clinical findings of this research may contribute toward the future betterment of care for all potential kidney donors and that this data may expand upon the limited information available in this important field of study. As a patient belonging to this Living Donor Transplant Community, you have the right to direct how your information is shared for use by research platforms. You may engage with the principal investigator of this study should you have any queries regarding how the data from this study is being applied. You may also withdraw consent to share any information you feel is potentially identifying at any point. Should you require any further information regarding the study, please feel free to contact the principal investigator, Dr Chandni Dayal via email

chandni.dayal@wits.ac.za

or telephonically on 011 489 0467. Please note that prior to accessing your clinical records, approval was obtained from the Human Research Ethics Committee (Medical) of the University of the Witwatersrand, Johannesburg. A principal function of this Committee is to safeguard the rights and dignity of all individuals who are a part of research projects and the integrity of the research. If you have any complaints or concerns over the way the study was conducted, please contact the Chairperson of this Committee who is Dr. Clement Penny, on telephone number 011 717 2301, or by e-mail

Clement.Penny@wits.ac.za

The telephone numbers for the Committee secretariat are 011 717 2700/1234 and the e-mail addresses are Zanele.Ndlovu@wits.ac.za and Rhulani.Mukansi@wits.ac.za Thank you for reading this notice. 11 March 2022 Dr Chandni Dayal

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Author: search.filters.author.Gathara, LindaSubject: search.filters.subject.Kidney Transplantation

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    Outcomes of cadaveric renal transplantation in patients using mycophenolate mofetil or azathioprine
    (2016-10-12) Gathara, Linda
    Introduction: Mycophenolate Mofetil (MMF) has replaced Azathioprine (AZA) in immunosuppressive regimens worldwide in the prevention of acute allograft rejection. Whether long term treatment with MMF is superior to treatment with AZA is a matter of debate. There are no studies in South Africa that have been done to show that MMF is superior to AZA. Objectives: To describe the outcomes of cadaveric renal transplantation in patients using Mycophenolate Mofetil or Azathioprine over a five year period at the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). Design: This was a retrospective comparative study. Setting: The CMJAH Renal Transplant Unit in Johannesburg, Republic of South Africa. Patients: A convenience sample of all eligible patients, 208 in total, was recruited from the Renal Transplant Unit at CMJAH. Methods: The study was approved by the University of the Witwatersrand Human Research Ethics Committee (Medical) (Protocol Number: M130434). The data source was clinical records of renal transplant recipients at the Renal Transplant Unit at CMJAH from 1985-2013, who were treated with one of the two immunosuppressive agents required for analysis in the study. The data were entered in Microsoft Excel Spreadsheets and transferred to STATA version 14 for statistical analysis. Results: Of the 208 patients, 101 patients were treated with Azathioprine and 107 patients treated with Mycophenolate Mofetil, in addition to corticosteroids and cyclosporine. A total of 16 patients developed acute allograft rejection 12-52 weeks after cadaveric transplantation. Of these, 6% were in the AZA group and 10 % in the MMF group. There was a mortality rate of 1% in the MMF and 16.8% in the AZA group respectively (p= 0.0001). The serum creatinine at 3 months was found to be a strong predictor of allograft function in patients on Mycophenolate Mofetil (p<0.001). After adjusting for the confounders, serum creatinine at 3 months remained a strong predictor of outcome. Patients experiencing abdominal pain while on treatment with Mycophenolate Mofetil were 62% less likely to develop acute allograft rejection than patients on treatment with Azathioprine [unadjusted HR = 0.38(0.14-1.05)]. This finding however, is not statistically significant (p=0.06). After adjusting for the other confounders the association with abdominal pain was marginally significant (adjusted HR 0.18(0.01-1.02) p=0.05). Conclusions: Patient survival was superior in the longterm in cadaveric renal transplant patients receiving Mycophenolate Mofetil therapy.
If you, your family member or spouse was involved in the clinic , we urge you to read the notice above. You are welcome to comment on the data, express concerns or ask for changes in how the data is being shared. The library holds data in safekeeping for the researcher, for the community and for the sake of open science. You can contact the curator of the collection: Data Services Librarian: Nina Lewin at email

nina.lewin@wits.ac.za

or telephonically on 0814121940.