Nephrology

Permanent URI for this collectionhttps://wiredspace.wits.ac.za/handle/10539/32807

This collection contains data collected in the course of clinical work in Nephrology across several hospitals In particular , the CMJAH Living Donor Clinic has a long history . You can see that the work of the unit has inspired or directly produced many thesis. We also have a selection of work on transplants. This collection also includes data on kidney disease from other tertiary hospitals in gauteng

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PARTICIPANT NOTICE OF DATA SHARING FOR STUDY TITLED ‘EVALUATION OF POTENTIAL KIDNEY DONORS AND OUTCOMES POST-DONATION AT CHARLOTTE MAXEKE JOHANNESBURG ACADEMIC HOSPITAL (1983-2015)’.

Good day, The Division of Nephrology at Charlotte Maxeke Johannesburg Academic Hospital ( Previously JHB GEN)conducted a research study in the unit’s Living Donor Clinic. The study assessed clinical data of all individuals who presented to this clinic from January 1983 to July 2015. Written permission to access clinical records was obtained from the Human Research Ethics Committee (Medical) of the University of the Witwatersrand, Johannesburg. The purpose of the study was to analyze living kidney donation in the South African setting with the hope that the clinical findings of this research may contribute toward the future betterment of care for all potential kidney donors and that this data may expand upon the limited information available in this important field of study. As a patient belonging to this Living Donor Transplant Community, you have the right to direct how your information is shared for use by research platforms. You may engage with the principal investigator of this study should you have any queries regarding how the data from this study is being applied. You may also withdraw consent to share any information you feel is potentially identifying at any point. Should you require any further information regarding the study, please feel free to contact the principal investigator, Dr Chandni Dayal via email

chandni.dayal@wits.ac.za

or telephonically on 011 489 0467. Please note that prior to accessing your clinical records, approval was obtained from the Human Research Ethics Committee (Medical) of the University of the Witwatersrand, Johannesburg. A principal function of this Committee is to safeguard the rights and dignity of all individuals who are a part of research projects and the integrity of the research. If you have any complaints or concerns over the way the study was conducted, please contact the Chairperson of this Committee who is Dr. Clement Penny, on telephone number 011 717 2301, or by e-mail

Clement.Penny@wits.ac.za

The telephone numbers for the Committee secretariat are 011 717 2700/1234 and the e-mail addresses are Zanele.Ndlovu@wits.ac.za and Rhulani.Mukansi@wits.ac.za Thank you for reading this notice. 11 March 2022 Dr Chandni Dayal

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Author: search.filters.author.Boosi, ReeceStart date: 2020

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    The influence of dialysis modality on post-transplant outcomes
    (2020) Boosi, Reece
    Introduction: Renal transplantation is the therapy of choice for end stage kidney disease, offering mortality risk reduction and improved morbidity over dialytic therapies. Limited data is available evaluating the effect of pre-engraftment dialysis modality on transplant outcomes. Methods: A retrospective review was conducted of all adult patients undergoing renal transplantation at Charlotte Maxeke Johannesburg Academic Hospital for the period 01/01/2006 – 31/12/2011 (n=103). Transplant outcomes were assessed by dialysis modality. c2 testing was used to compare dialysis modalities; Cox proportional hazard modelling was used to assess effect on graft outcomes. A p < 0.05 was deemed statistically significant. Results: Antecedent dialytic modality was as follows: 55 patients (53.4%) received haemodialysis (HD), 35 (34%) received peritoneal dialysis (PD), and 13 (12.6%) received a combination of both (HD+PD, defined as either modality for > 3 months). Acute rejection (AR) was documented in 43.7% of patients; 54.3% of PD patients developed AR compared to 38.2% of HD patients and 38.5% of HD+PD patients (p=0.29). No significant difference in the number of episodes of AR was detected between modality groups (p=0.44). Chronic rejection (CR) developed in 22.3% of patients overall; 21.8% of HD patients, 25.8% of PD and 15.9% of HD+PD patients (p=0.74). PD was associated with an increased risk of developing any rejection (HR=2.4, 95% CI 0.9–6.4, p=0.02). Whereas dialysis modality did not affect graft survival (for HD b= 0.57, SE=0.5, Wald=1.2, 95% CI -0.4-1.6, p=0.27; for PD b=0.58, SE=0.5, Wald = 1.4, 95% CI -0.4-1.6, p=0.24), AR was found to be associated with futuregraft loss (b=1.29, SE=0.3, Wald = 18.1, 95% CI 0.7-1.9, p<0.001).Conclusions: Antecedent PD is associated with an increased risk of graft rejection. Although AR is associated with graft loss, antecedent dialysis modality does not directly predict graft survival, likely reflecting the multifactorial nature of cumulative allograft injury.
If you, your family member or spouse was involved in the clinic , we urge you to read the notice above. You are welcome to comment on the data, express concerns or ask for changes in how the data is being shared. The library holds data in safekeeping for the researcher, for the community and for the sake of open science. You can contact the curator of the collection: Data Services Librarian: Nina Lewin at email

nina.lewin@wits.ac.za

or telephonically on 0814121940.