ETD Collection

Permanent URI for this collectionhttps://wiredspace.wits.ac.za/handle/10539/104


Please note: Digitised content is made available at the best possible quality range, taking into consideration file size and the condition of the original item. These restrictions may sometimes affect the quality of the final published item. For queries regarding content of ETD collection please contact IR specialists by email : IR specialists or Tel : 011 717 4652 / 1954

Follow the link below for important information about Electronic Theses and Dissertations (ETD)

Library Guide about ETD

Browse

Filters

2014 - 201912020 - 20211

Settings

Author: search.filters.author.Nyati, Howard LukhanyoHas files: Yes

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Factors influencing growth and body composition through early adolescence to young adulthood
    (2021) Nyati, Howard Lukhanyo
    Objectives Obesity is a global pandemic, and its rise is associated with a higher risk of non-communicable diseases (NCD). The prevalence of obesity is rising faster in low- and middle-income countries (LMIC) contributing to an epidemiological transition from communicable to NCD. A life-course approach can give insight into critical periods during which increases in obesity incidence occur and changes in adolescent body composition may be associated with adult obesity. Therefore, the aims of this thesis in a cohort of South African urban children were, to (i) assess age-related changes in the prevalence of overweight and obesity and growth and comparing percentiles between race groups and international reference; (ii) characterise racial differences in height, weight and body mass index (BMI) during adolescence; (iii) assess the association between early childhood growth and the magnitude, timing and intensity of adolescent growth; (iv) assess the association between the magnitude, timing and intensity of adolescent growth and young adult body composition; (v) assess the association between adolescent BMI and adult body composition in relation to biological maturity. Methods This thesis analysed data from prospective longitudinal Birth to Twenty Plus (Bt20+) cohort. A total of 5449 children born in the City of Johannesburg municipal region of South Africa from the 23rd of April to the 8th of June in 1990 were screened for enrolment. A total of 3273 (78% black, 12% coloured, 4% Indian & 6% white) singleton newborns with no congenital defects, born to mothers who had permanent residence or continued residence for 6 months were included in the study. Anthropometric data were collected from birth to 24 years using standard techniques. Dual x-ray absorptiometry (DXA) was used to measure body composition (whole body and abdominal fat mass and whole-body lean mass) from age 21 to 24 years. Data were converted to age and sex specific z-scores for height (height-for-age, HAZ), weight (weight-for-age, WAZ and weightfor-length, WHZ) and BMI (BMI-for-age, BMIZ) using the World Health Organisation (WHO) 2006 child growth standards to determine the prevalence of stunting, underweight and wasting using the cut-off of -2SDs, from birth to 5 years. Overweight and obesity from 2 to 18 years was determined using the age- and sex-specific cut-offs from the International Obesity Taskforce (IOTF). The lambda, mu and sigma (LMS) method was used to generate age- and sex-specific percentiles for height, weight and BMI from 2 to 19 years. Longitudinal changes in anthropometric characteristics (height, weight and BMI) were modelled using the superimposition by translation and rotation (SITAR) method from age 7 to 23 years. The model summarised growth using three random effects; size (magnitude), tempo (timing) and velocity (intensity). Associations between growth in early childhood and growth in adolescence, as well as between growth in adolescence and body size & composition in adulthood, were assessed using linear regression models. Results There were ethnic and sex differences in the prevalence of early childhood undernutrition and overweight and obesity in adolescence. Black males had the highest prevalence of stunting (34.4%) at 2 years of age, compared to 16.7%, 24.9% and 0.0% in white males, black females and white females, respectively. Black females had the highest prevalence of overweight/obesity (46.5%) at 21+ years compared to 26.1%, 14.9%, and 29.4% in white females, and black and white males respectively. The 50th percentile for height for black males was similar to the 10th percentile for South African white males and CDC reference. The 50th percentile for waist circumference for black females approached the 10th percentile of the NHANESIII reference while the 50th percentile for BMI and weight for black females was similar to the 50th centile of CDC reference. Black males also experienced an 8-month delay in the timing of age of peak height velocity (APHV) compared to white males, while black females had a 3-month earlier APHV than white females. Early childhood growth explained a greater variance of the magnitude of the adolescent growth spurts for height, weight, and BMI (range: 19.3 to 52.3%) than it did for timing (range: 5.5 to 15.2%) and intensity (range: 2.1 to 10.8%). In turn, the magnitudes of adolescent weight and BMI gain were the strongest predictors of young adult BMI, fat mass, fat-free soft tissue mass, fat mass index (FMI) and fat-free soft tissue mass index (FFMI), than the timing and intensity of weight and BMI. Adolescent weight was also positively associated with young adult height. Achieving peak weight gain before APHV was associated with greater fat mass and FMI than after APHV in females. Childhood onset overweight/obesity is associated with greater BMI, whole body and trunk fat mass percent than late adolescence onset overweight/obesity Conclusion This thesis used a lifecourse approach to address two important global health problems which are plaguing LMIC, the persistently high prevalence of undernutrition and the emerging obesity pandemic. There are additional periods of growth faltering and residual plasticity in black children. Thus, there are several windows of opportunity to influence growth: 1) in foetal/infancy and prepubertal periods to promote optimal linear growth, 2) childhood to early adolescence to prevent unhealthy and persistent body mass gain, and 3) late adolescence to prevent the resurgences of weight and BMI velocities in women. Long-term (childhood onset) obesity could have more adverse effects for cardiometabolic disease risk than late adolescent onset obesity.
  • No Thumbnail Available
    Item
    Racial differences in the growth of the axial and appendicular skeleton and bone mass in 11 year old South African children.
    (2014-03-28) Nyati, Howard Lukhanyo
    Introduction Ethnic differences in bone growth and proportions have previously been investigated in relation to bone fragility. Differential growth in the axial and appendicular skeletons has been suggested to predispose to differential susceptibility to fracture. The developmental origins of bone size and osteoporosis have also been investigated. However, the impact of foetal programming on body proportions and limb lengths in unknown. Objectives The aim of this study was to investigate the presence of ethnic and sex differences in axial and appendicular growth. Additionally, it was to investigate the impact of early life factors on skeletal dimensions and proportions in childhood . Methods Anthropometric measurements of stature, weight, sitting height and limb lengths were taken on 368 black and white, male and female 9 year old children. DXA scans of the distal ulna;distal radius; hip and lumbar spine were also obtained. The same measurements were obtained for 197 of the black children who had birthweight and weight and length data at 1 year. For the first part of the analyses, Analyses of Covariance were performed to assess differences in limb lengths adjusted for differences in stature. Multiple regression analyses were used to assess significant predictors of site-specific bone mass. Comparisons were made after adjustment for weight, weight and stature and weight and regional segment lengths. For the second part of the analyses, Analyses of Covariance were performed to assess differences in stature and regional segment lengths at different tertiles of birthweight, and weight and height at 1 year. Stepwise multiple regressions were performed with early life growth patterns to assess significant predictors of stature and regional segment lengths at 10 years. Results Black children had longer limbs but shorter trunks than white children. Regional segment length were a more significant predictor of site-specific bone mass than stature. In black boys birthweight had positive but weak associations with stature and regional segment length while in girls the association were marginal. In contrast, weight and height at 1yr had strong associations with stature and regional segment lengths. Conclusion There is a differential effect of ethnicity and sex on the growth of the axial and appendicular skeletons, and regional segment length is a better predictor of site-specific bone mass than stature. Early life growth has a long-term influence on stature, as well as on regional segment lengths but marginal effect on body proportions.