ETD Collection

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Author: search.filters.author.De Almeida, Maria, RosarioSubject: search.filters.subject.Plasmodium falciparum

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    An investigation of p-glycoprotein in plasmodium falciparum and the isolation of haemozoin
    (1992) De Almeida, Maria, Rosario
    Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptical parasites, and this is thought to be the basis of their resistance ( Fitch, 1970 ). Martin et. al ( 1987 ), recently demonstrated that in the presence of verapamil, a calcium channel blocker, chloroquine-resistant P falciparum becomes chloroquine-sensitive, with an increase in the chloroquine accumulation.The mechanism of such reversal has yet to be elucidated