ETD Collection

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Author: search.filters.author.Da Cruz, Isabel Maria Rosa

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    Effect of diet on carnitine and lipid metabolism with particular reference to Kwashiorkor
    (1991) Da Cruz, Isabel Maria Rosa
    Carnit ine plays a role in the transport of act iva ted long chain fatty acyl groups from the site of activation to the site of beta-oxidation in the mitochondria. Endogenous synthesis of ca.rnitine from the amino acids methionine and lyslne~ takes place mainly in the liver. Fl.'om i:here free and acyl caen.itine are re 1eased into the blood and transported to other tissues. A few studies have indicated that poor nutrit.ional status may Idad to carnitin€ defic'lency. There is a high prevalence of Itwashiorkol; p a. prot ein-enel~gy de f Ie 1an t state p among's t the 1::1a1ck popul at ion in Southern A:h~ica , but at present littie is known concerning carnitine and i is poasible effects on lipid met abo I I sm, Furthermore ther\';! have been relatively few studies concerning the effects of different diets on serum e arn i t Lne and lipid. So fa.r no reports have been pub l I shed concerning the e fisc t,a 0.£ l\&,li, ze meal as a a t apI e di is t , Thi s is 'highly relevarAt in the South African context. The aims of the present study WEll'e to oompare serum carnitine, protein and lipids in blaclt and white Sou.th African adu l ts, to evah.ls1:e tbe effect of a high maI Z~ diet (10W-Pl~otein) on. heal thy adu] t IS and to mves t ignte these parametet's in chi Idren wi th Itws.shiorltol' as compa.!' ed wi th normal chi Idl'en as well as to assess the re.sponse to treatment in the :aut!"i tionally depl~ived group. tn the p'reserl't study no ma]or c'u. fferences wel;e observed '!:nlltvJ'een the diffel~·ent adult population groups; va l ue s for "ormal children wer8 In general within similar lahlss. A change to a IDw~pratein diet in healthy whi t e adu l t s produced signi. ficant di ffer811ces in carn. I t t ne and the proteins and lipiiis measured. The values "btained for the lrwashiorlwl' chi Ldren showed aigniticaA~t Changes as compared with no rma l eht t dr en, En par t f cut s« cam it Ine and total phospholipid eonc~ nt'J.'fations wel'l;; sig'oi Hcsnt 11 reduced and the percentag~ of doc(llsatetra~noic acid (22:4) was increased. The results obtained sugg~~t that there may be impaired o2idatioil of lipids' in ktt'H1Shiol'KOr and the deficiency of carnt ti ne may provide an exp Lanat ion for the aceumuIat f cn of fats in the livers of Itwashiorltol' patients. The de or e a se in total phospholipid concentration with a lt erat Lons in the lecithin fatty acid distribution in the ~hildren suggest that there may be changes ih membrane fluidity and fleXibility.
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    Effect of diet on carnitine and lipid metabolism with particular reference to kwashiorkor
    (1991) Da Cruz, Isabel Maria Rosa
    Carnitine plays a role in the transport of activated long chain fatty acyl groups from the site of activation to the site of beta-oxidation in the mitochondria. Endogenous synthesis of carnitine from the amino acids methionine and lysine, takes place mainly in the liver. From there free and acyl carnitine are released into the blood and transported to other tissues.A few studies have indicated that poor nutritional status may lead to carnitine deficiency.[Abbreviated Abstract. Open document to view full version]