Browsing by Author "Kerstin Klipstein-Grobusch"
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Item Adiposity phenotypes and subclinical atherosclerosis in adults from subSaharan Africa a H3AfricaAWIGen studyE Nonterah; M Bots; A Oduro; G Agongo; Cassandra Soo; Lisa Micklesfield; Alisha Wade; Shane Norris; Stephen Tollman; Michele Ramsay; Kerstin Klipstein-Grobusch; Nigel CrowtherItem Advancing noncommunicable diseases research in Ghana Key stakeholders recommendations from a symposiumP Tindana; Michele Ramsay; Kerstin Klipstein-Grobusch; M Amoakoh-ColemanItem Cardiovascular Risk Factor Burden and Association With CKD in Ghana and NigeriaT Olanrewaju; C Osafo; Y Egigogo Raji; M Mamven; Kerstin Klipstein-Grobusch; E et alItem Carotid Atherosclerosis, Microalbuminuria, and Estimated 10-Year Atherosclerotic Cardiovascular Disease Risk in Sub-Saharan Africa(2022-04-01) Engelbert A Nonterah; Daniel Boateng; Nigel J Crowther; Kerstin Klipstein-Grobusch; Abraham R Oduro; Godfred Agongo; Shukri F Mohamed; Palwendé R Boua; Solomon S R Choma; Shane A Norris; Stephen M Tollman; Michiel L Bots; Michèle Ramsay; Diederick GrobbeeImportance: Carotid atherosclerosis and microalbuminuria are associated with atherosclerotic cardiovascular disease (ASCVD) but are understudied in sub-Saharan Africa. Objective: To evaluate the association of carotid atherosclerosis and microalbuminuria with 10-year ASCVD risk in middle-aged sub-Saharan African individuals. Design, setting, and participants: This cross-sectional study conducted analyses of baseline data from the African-Wits-INDEPTH (International Network for the Demographic Evaluation of Populations and Their Health in Low- and Middle-Income Countries) genomic study (AWI-Gen). Women and men aged 40 to 60 years without baseline CVD and drawn from Burkina Faso, Ghana, Kenya, and South Africa were included. Main outcomes and measures: Hypotheses for the analyses were formulated after data collection. The main exposures were carotid atherosclerosis, assessed using carotid intima-media thickness (CIMT) using B-mode ultrasonography, and microalbuminuria, measured using spot urine albumin (SUA) and urine albumin-creatinine ratio (uACR). The main outcome was high ASCVD risk, defined as a 2018 Pooled Cohort Equations score of 7.5% or greater. Associations were estimated using adjusted multivariable logistic regression analyses. Findings: A total of 9010 participants with a mean (SD) age of 50 (6) years and 4533 (50.3%) women were included. High CIMT, SUA, and uACR were each associated with older age (eg, mean [SD] age of participants with high vs reference range CIMT: 55 [5] years vs 50 [6] years; P < .001) and high prevalence of both diabetes and hypertension (eg, hypertension among those with high vs reference range SUA: 213 of 1117 [19.1%] vs 356 of 2549 [14.0%]; P < .001). Smokers were likely to have higher vs reference range SUA (210 [18.8%] vs 407 [16.0%]) and uACR (138 of 707 [19.5%] vs 456 of 2797 [16.3%]). Carotid atherosclerosis was common in Burkina Faso (82 of 262 [31.3%]) and Ghana (91 [34.7%]), while microalbuminuria, measured by SUA, was common in Kenya (272 [24.4%]) and South Africa (519 [46.5%]). SUA was associated with higher odds of carotid atherosclerosis (odds ratio [OR], 1.77; 95% CI, 1.04-3.01) compared with uACR (OR, 0.51; 95% CI, 0.27-0.95). Common CIMT, SUA, and uACR were associated with 10-year ASCVD risk, with CIMT having a stronger association with 10-year ASCVD risk in both women (OR, 1.95; 95% CI, 1.78-2.14) and men (OR, 1.73; 95% CI, 1.55-1.93) than SUA (women: OR, 1.29; 95% CI, 1.12-1.43; men: OR, 1.46; 95% CI, 1.26-1.55) and uACR (women: OR, 1.32; 95% CI, 1.10-1.54; men: OR, 1.35; 95% CI, 1.15-1.46). Conclusions and relevance: The presence of microalbuminuria measured by SUA may indicate risk of subclinical carotid atherosclerosis and high 10-year ASCVD risk in middle-aged residents of sub-Saharan Africa. These data should be confirmed in longitudinal studies of cardiovascular events.Item CommunityBased Strategies to Improve HealthRelated Outcomes in People Living With Hypertension in Low and MiddleIncome Countries A Systematic Review and MetaAnalysisS Nyame; D Boateng; P Heeres; Joyce Gyamfi; E et al; Kerstin Klipstein-GrobuschItem Completeness of obstetric referral lettersnotes from subdistrict to district level in three rural districts in Greater Acraa region of Ghana an implementation research using mixed methodsM Amoakoh-Coleman; E Ansah; Kerstin Klipstein-Grobusch; D ArhinfulItem Course of disease and clinical outcome of infective endocarditis in HIVinfected individuals A systematic review and metaanalysisJ Bos; C Antonides; R Barth; Kerstin Klipstein-Grobusch; Ruchika Meel; Alinda VosItem Determinants of coronary artery disease risk factor management across three world regionsM Zhao; I Graham; M Cooney; D Grobbee; I Vaartjes; Kerstin Klipstein-GrobuschItem Early life ambient air pollution household fuel use and under5 mortality in Ghana(PERGAMON-ELSEVIER SCIENCE LTD) A Moro; E Nonterah; Kerstin Klipstein-Grobusch; S Oladokun; P Welaga; P Ansah; E "et al"Item Earlylife exposures and cardiovascular disease risk among Ghanaian migrant and home populations the RODAM studyD Boateng; I Danquah; Rihlat Said-Mohamed; L Smeeth; M Nicolaou; E et al; Kerstin Klipstein-GrobuschItem The effect of exposure to traffic related air pollutants in pregnancy on birth anthropometry a cohort study in a heavily polluted lowmiddle income country(BIOMED CENTRAL LTD) F Soesanti; C S PM Uiterwaal; K Meliefste; J Chen; Kerstin Klipstein-Grobusch; E et alItem Effectiveness of selffinancing patientled support groups in the management of hypertension and diabetes in low and middleincome countries Systematic reviewR E Sanya; E S Johnston; P Kibe; M Werfalli; Kerstin Klipstein-Grobusch; E et alItem Epigenomewide association study of plasma lipids in West Africans the RODAM studyE L van der Linden; K A C Meeks; F Chilunga; C Hayfron-Benjamin; Kerstin Klipstein-Grobusch; E et alItem Genomewide DNA methylation analysis on Creactive protein among Ghanaians suggests molecular links to the emerging risk of cardiovascular diseasesF Chilunga; P Henneman; Andrea Venema; Karlijn A. C Meeks; E et al; Kerstin Klipstein-GrobuschItem A Global Perspective on Cardiovascular Risk Factors by Educational Level in CHD Patients SURF CHD IIA Marzà-Florensa; I Vaartjes; I Graham; Kerstin Klipstein-Grobusch; D Grobbee; E et alItem Green space visits among Turkish and South Asian Surinamese women with a high cardiometabolic risk living in disadvantaged neighborhoods in the Netherlands motives means and prerequisites(BIOMED CENTRAL LTD) L van den Brekel; H. R Voogdt-Pruis; L Wispelweij; L Jawalapershad; Kerstin Klipstein-Grobusch; E et alItem Hypertension knowledge attitudes and perceptions among adults in the Navrongo Health and Demographic Surveillance Site a mixed methods analysisA Singh; G Agongo; S Chatio; B Logonia; Kerstin Klipstein-Grobusch; E et alItem Is social support associated with hypertension control among Ghanaian migrants in Europe and nonmigrants in Ghana The RODAM studyG Nyaaba; K Stronks; K Meeks; E Beune; Kerstin Klipstein-Grobusch; E et alItem Maternal and neonatal outcomes following the introduction of oral hypoglycaemic agents for gestational diabetes mellitus were comparable to insulin monotherapy in two historical cohortsVeronique Nicolaou; Larske Soepnel; Kenneth Huddle; N Levitt; Kerstin Klipstein-Grobusch; Shane NorrisItem Microvascular and macrovascular complications in type 2 diabetes Ghanaian residents in Ghana and Europe The Rodam studyC Hayfron-Benjamin; B Van den Born; M Van der Zee; A Amoah; Kerstin Klipstein-Grobusch; E et al