The prevalence of cutaneous lupus manifestations in patients diagnosed with Systemic Lupus Erythematosus (SLE) attending the Chris Hani Baragwanath academic hospital rheumatology outpatient clinic

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dc.contributor.authorKoch, Karen
dc.date.accessioned2020-12-11T11:08:47Z
dc.date.available2020-12-11T11:08:47Z
dc.date.issued2017
dc.descriptionSubmitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfillment of the requirements for the degree of Master of Medicine in Dermatologyen_ZA
dc.description.abstractIntroduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder. The skin is affected in up to 85% of cases. Aims The objective of this study was to determine the prevalence and spectrum of both specific and non-specific cutaneous findings in SLE patients attending Chris Hani Baragwanath Academic Hospital. Methods A retrospective record review of 298 patients meeting the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria for SLE. Cutaneous findings were divided into LE- specific disease (Cutaneous Lupus Erythematosus) and LE-nonspecific findings. The Lupus Severity Index (LSI) was calculated according to the Bello et al. Results The mean (SD) age at presentation was 35 years (11.8) and the female: male ratio was 13:1. Eighty-three percent of patients had cutaneous findings and CLE affected 76.1% of patients. Discoid Lupus Erythematosus (DLE) was the commonest form of CLE followed by Acute Cutaneous Lupus Erythematosus (ACLE). Patients with CLE had a significantly better Lupus Severity Index (LSI) (5.7 vs 6.1; p=0.001). Those patients with Chronic Cutaneous Lupus Erythematosus (CCLE) had a better LSI than those with ACLE (6.07 vs 6.5; p=0.001). Conclusion The skin was the single most commonly affected organ system. DLE, both localised and generalised, was very common in patients with SLE, occurring more frequently than ACLE. Patients with CLE had a better LSI than those without.en_ZA
dc.description.librarianKP2020en_ZA
dc.facultyFaculty of Health Sciencesen_ZA
dc.identifier.citationKoch K. The prevalence of cutaneous lupus manifestations in patients diagnosed with Systemic Lupus Erythematosus (SLE) attending the Chris Hani Baragwanath academic hospital rheumatology outpatient clinic. University of Witwatersrand: Johannesburg. 2017en_ZA
dc.identifier.urihttps://hdl.handle.net/10539/30353
dc.language.isoenen_ZA
dc.subject.meshLupus Erythematosus, Systemic
dc.titleThe prevalence of cutaneous lupus manifestations in patients diagnosed with Systemic Lupus Erythematosus (SLE) attending the Chris Hani Baragwanath academic hospital rheumatology outpatient clinicen_ZA
dc.typeThesisen_ZA
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