the practice and usefulness of bone marrow examinations in a cohort of human immunodeficiency virus infected children in South Africa: a descriptive study
| dc.contributor.author | Rowe, Biance | |
| dc.date.accessioned | 2012-01-11T06:27:04Z | |
| dc.date.available | 2012-01-11T06:27:04Z | |
| dc.date.issued | 2012-01-11 | |
| dc.description.abstract | INTRODUCTION: Bone marrow examination (BME) is performed in Human Immunodeficiency Virus-infected (HIV+) children with haematologic abnormalities to exclude specific disease (SD). AIMS: To describe the: (1) indications for BME , (2) utility of BME to diagnose SD, (3) patient characteristics associated with SD or non-specific disease (NSD). METHODS: Design: Retrospective review. Definitions: SD: BME positive for opportunistic infection (OI) or HIV-related malignancy. NSD: HIV-related changes only. RESULTS: Eighty six BME’s were done. Suspected SD in 56/86(65.1%) was the most common clinical indication. Bicytopaenia(n=32) and isolated cytopaenia(n=31) were the most common haematologic indications. NSD 48/86 (55.8%) was a more common finding than SD 32/86 (37.2%). Granulomas, pure red cell aplasia and malignancy were the SD identified. Pre- highly active antiretroviral therapy (HAART), advanced stage, and not being virally suppressed were significantly associated with NSD. CONCLUSION: The yield of SD (37.2%) on BME is comparable to adult studies. HAART should be instituted before BME as NSD will be the most likely finding. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10539/10962 | |
| dc.language.iso | en | en_US |
| dc.subject | children with HIV | eng |
| dc.subject.mesh | Bone Marrow Examination | en-US |
| dc.title | the practice and usefulness of bone marrow examinations in a cohort of human immunodeficiency virus infected children in South Africa: a descriptive study | en_US |
| dc.type | Thesis | en_US |