Evaluation of cardiac surgery associated acute kidney injury using ultrasound
Date
2021
Authors
Pettey, Gabriela
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Abstract
Abstract: The contemporary definition of the diagnosis of acute kidney injury (AKI) is neither timesensitive, nor specific. AKI is notoriously multifactorial in origin and found to occur more commonly in cardiac surgery patients when compared to non-cardiac surgery patients. Cardiac surgery associated acute kidney injury (CSA AKI) carries substantial morbidity and mortality. Pursuits to timeously diagnose CSA AKI have, to date, not been actualized. We
investigated the use of hepatic venous and right heart ultrasound parameters in predicting CSA AKI. Methods: The study was a prospective contextual and descriptive two-center study. The sites of the study were Johannesburg, South Africa, and Aarhus, Denmark. Adult patients that satisfied inclusion criteria, between August 2019 and January 2020 were included, with a total of 152 participants. Blood tests, clinical and ultrasound data were obtained pre-operatively, day-1 and day-4 post-operatively. Hepatic vein, Inferior vena cava and right heart Doppler ultrasound parameters were obtained and analysed for abdominal venous hypertension and the development of AKI. Results: The median (IQR) age of patients was 68 (55-73) years, predominantly male and the majority were hypertensive. Of 152 patients analysed, 54 (35 %) patients developed AKI. Among these, 37 (69 %) were classified as KDIGO stage I, 11 (20 %) in stage II, whilst 6 (11 %) were in stage III. Age [AOR 1.05, 95%CI 1.00-1.10 P=0.031], EuroSCORE II [AOR1.43, 95%CI 1.14-1.80, P=0.005] and pre-operative serum creatinine [AOR 1.04, 95%CI 1.01- 1.08, P = 0.013] were predictive of AKI. Those who developed AKI had experienced longer cardiopulmonary bypass (CPB) times (P<0.001). Pre-operatively hepatic vein S wave measurements were significantly higher in patients with AKI (P<0.05). On post-operative day-1, hepatic vein flow ratios of patient with AKI were significantly decreased, driven by low S waves and high D waves, accompanied by significantly elevated central venous pressure (CVP) levels. CVP levels on day-1 (D1) post-operatively were predictive of AKI [AOR 1.31, 95%CI 1.11-1.55, P = 0.001]. Conclusion: Pre-operative hepatic vein S waves were higher in those who developed AKI. This
phenomenon seemed to precede the decrease in D1 hepatic flow ratios driven by low S waves and high D waves. The element of venous congestion was reflected by significantly elevated CVP values which were independently associated with AKI on D1. These parameters may reflect peri-operative circumstances including prolonged CPB times, and potential fluid management aspects that can be modified peri-operatively.
Description
A research report submitted to the Faculty of Health Sciences, School of Clinical Medicine, University of the Witwatersrand, in partial fulfilment for the degree of a Masters in Medicine, in the branch of Anaesthesia