Investigating the health profile of employees at a pharmaceutical company in Johannesburg
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Date
2020
Authors
Da Silva, Margarida Pereira
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Abstract
BACKGROUND: Obesity is a pandemic that has grown dramatically over the recent thirty years.
It is a disease that is associated with non-communicable diseases and is considered a public health
concern. Populations in the sub-Saharan African region are particularly vulnerable to obesity and
co-morbid diseases. Existing and emerging research demonstrates that employed African
populations are also at risk for obesity and related cardiometabolic diseases, which can negatively
impact workplace health and productivity. Further research is required to address these concerns.
AIM: The master’s research project aimed to determine the health profile and risk factors
associated with obesity and related cardiometabolic diseases amongst employees in a
pharmaceutical company in Johannesburg, South Africa.
METHODS: The study used a cross-sectional, observational study design. This study recruited
145 study participants, who were employees at Ascendis Health Supply Chain and of which 86
were female. Anthropometric data (height, weight, waist, hip, and calf circumference), automated
blood pressure, total cholesterol, and random glucose were measured using standard protocols. The
following self-reported questionnaires were also conducted: The Global Physical Activity
Questionnaire (GPAQ) was used to determine physical activity and sitting time; estimated beverage
consumption was collected with the Beverage Intake Questionnaire (BEV-Q 15), while self reported sleep duration was determined using the Pittsburgh Sleep Questionnaire Index (PSQI);
the Centre for Epidemiologic Studies Depression Scale (CESD-R) was used to determine self reported depression; smoking, alcohol consumption, and basic dietary behaviour were collected
using the Discovery Health Index Questionnaire; and absolute absenteeism was determined using
the Health and Work Performance Questionnaire. Objective free-living data, physical activity,
inactivity, and sleep were collected using Axivity wrist-worn monitors. Descriptive data were
presented as mean ± standard deviation or median (interquartile range) in tables. Univariate
analysis and multiple linear regression analysis were performed to determine the association of
behavioural factors with anthropometry, obesity, cardiometabolic diseases, and sickness absence.
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RESULTS: The mean ± standard deviation (SD) age of the study population was 39.4 ± 10.1
years, with mean years at work for all participants being 5.9 ±7 years. The total number of sick
leave days was 14.4 ± 14.2 days, with females taking more days off than males 16.4 ± 14.4 vs 11.3
± 13.6, p = 0.032. Axivity monitors demonstrated lower MVPA and higher inactivity levels than
self-reported measures, with the greatest discrepancy noted in vigorous activity (median of 2.92
(0.99 – 5.89) mins/day (objective measure) versus median of 60 (0-360) mins/day (subjective
measure). Objective inactivity measures of 498.1 (450.7 – 563.8) mins/day were higher than self reported inactivity with mean of 180 (120 – 300) mins/day. Of the total study population, 34.5%
had an inadequate fruit and vegetables intake per day. The overall prevalence of hypertension was
42.8%. Females presented with a mean BMI of 31.5 ± 6.96, indicative of obesity, with males
showing to be overweight with a mean BMI of 26.8 ± 4.99. Altogether, 42.1% of the total
population showed to be obese with a BMI >30 kg˙m² and 32.4% were at risk of obesity with a
BMI between 25 and 29.9 kg˙m². The total population glucose levels were 6.47 ± 1.53, with a low
prevalence of self-reported diabetes type 2 at 3.4% of the total sample size. The total prevalence of
self-reported cholesterol was 6.9%, with a total population cholesterol level mean of 4.65 ± 0.68.
Alcohol consumption was considerably higher in males than females (88.5 ± 185 vs 39.3 ± 109 (p
= 0.047), respectively). A higher mean depression score was seen in females (8.97 ± 6.15) than
5.71 ± 4.66 in males, (p = 0.001). Females showed a higher PSQI score (6.2 ± 3.62) demonstrating
lower quality of sleep when compared to males (5.08 ± 2.82, p = 0.049). However, both males and
females obtained similar hours of sleep per night at a self-reported mean of 7.30 ± 1.19 hours of
the total population, 42.8% struggled to cope with stress, with 31.7% indicative of depression.
According to the Framingham 10-year CVD risk algorithm, a total of 21.4% of study population
showed to be at a moderate – high risk of developing cardiovascular disease. Moderate to vigorous
physical activity (mins/day) showed to decrease obesity risk by being inversely associated with
waist circumference (β: - 0.07, p = 0.02), CVD risk (β: - 0.04, p = 0.02) and sick leave (β: - 0.26,
p = 0.04). Current smoking status was positively associated with total cholesterol (β: 0.71, p =
0.005) whereas subjective light physical activity was negatively associated with total cholesterol
(β: - 0.00, p = 0.01). Total years at work (β: 0.27, p = 0.02), semi-skilled work (β: 0.27, p = 0.02),
depression total score (β: 0.22, p = 0.03) and subjective LPA (β: 0.25, p = 0.04), were positively
associated with total sick leave.
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CONCLUSION: The findings of this study show a high prevalence of obesity and hypertension
within this study population, demonstrating the need for these diseases to be addressed in the
workplace. Females showed to be at a greater risk for obesity and cardiometabolic disease in
comparison to males. Discrepancies were noted between subjective and objective measures of
physical activity, indicative of possible overestimation for self-reported physical activity levels.
Light physical activity and high depression scores were associated with sick leave, confirming the
urgent need to address mental health in employees within the workplace. Interventions to reduce
sugar intake, increase activity, particularly vigorous activity and address mental health in the
workplace could show beneficial in reducing risk factors and possibly improve absenteeism rates.
Description
A dissertation submitted in fulfilment of the requirements for the degree of Master of Science in Medicine to the Faculty of Health Sciences, School of Therapeutic Sciences, University of the Witwatersrand, Johannesburg, 2020