Serotonin antagonism in primate experimental myocardial infarction
No Thumbnail Available
Date
1992-10-07
Authors
Hartford, Craig Gordon
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Serotonin (5-Hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in the normal coronary circulation of various animal species. In the presence of coronary artery disease serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. This study tested the effect of ketanserin, a selective 5-HT2 receptor antagonist and platelet aggregation inhibitor, on ischaemic myocardium blood flow and coronary collateral formation following coronary artery occlusion in primates.
Description
A Dissertation submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg, for the Degree of Master of Science.