Haematological abnormalities in South Africans with systemic lupus erythematosus
| dc.contributor.author | Anafi, Ivy Yaa Gyamaa | |
| dc.date.accessioned | 2021-12-16T00:56:24Z | |
| dc.date.available | 2021-12-16T00:56:24Z | |
| dc.date.issued | 2021 | |
| dc.description | A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfilment of the requirements of the degree of Master of Medicine (Internal Medicine), 2021 | en_ZA |
| dc.description.abstract | Background: Little is known about haematological abnormalities in South Africans with systemic lupus erythematosus. Method: A retrospective-nested case-control study of 240 SLE patients, comparing baseline haematology and clinical features in 200 known alive (AG) and 40 known deceased (DG) patients. Results: Most patients were black (93.3%) and female (96.3%). Anaemia (70.8%) and lymphopaenia (58.8%) were the commonest haematological abnormalities. Compared to AG, DG had lower median haemoglobin (Hb) (9.5g/dl vs 10.8g/dl, p<0.01) and higher median red cell distribution width (RDW) (16.6fL vs 15.4fL, p= 0.01). Renal involvement was independently associated with anaemia and raised RDW >16fl (OR=2.52 and 1.85, respectively). Central nervous system involvement was associated with leucopaenia and neutropaenia (OR=2.61 and 3.26, respectively). Raised basophil count and RDW independently predicted death. Conclusion: Haematological abnormalities at diagnosis were common in this predominantly black African cohort of SLE patients, often associated with major organ involvement. Increased basophil count and RDW at diagnosis predicted mortality | en_ZA |
| dc.description.librarian | CK | en_ZA |
| dc.faculty | Faculty of Health Sciences | en_ZA |
| dc.identifier.uri | https://hdl.handle.net/10539/32345 | |
| dc.language.iso | en | en_ZA |
| dc.title | Haematological abnormalities in South Africans with systemic lupus erythematosus | en_ZA |
| dc.type | Thesis | en_ZA |