Genotoxicity of mycotoxins in an improved drosophila wing spot test and other short-term effects

Abstract

Attempts have been made recently to improve the Drosophiia Somatic Mutation and Recombination wing spot test (SMART) by inciudjig insecticide resistance genes that confer high bioactivation (HB) to SMART tester strains. A drawback of the HB lines is the presence of whorling of wing hairs which interferes with scoring for mutant spots. The gene responsible for this whorling effect, which I have named paisley (ply), was shown to be recessive and located around position 90 on chromosome 2 and is thus linked to the RI gene responsible for the high constitutive expression of cytochrome P450- dependent activities typical of HB strains. (Abbreviation abstract)