Downregulation of the Non-Integrin Laminin Receptor Reduces Cellular Viability by Inducing Apoptosis in Lung and Cervical Cancer Cells.

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dc.citation.doi10.1371/journal.pone.0057409en_ZA
dc.citation.issue3en_ZA
dc.contributor.authorMoodley, K.
dc.contributor.authorWeiss, S.F.T.
dc.date.accessioned2016-10-24T13:08:12Z
dc.date.available2016-10-24T13:08:12Z
dc.date.issued2013-03-05
dc.description.abstractThe non-integrin laminin receptor, here designated the 37-kDa/67-kDa laminin receptor (LRP/LR), is involved in many physiologically relevant processes, as well as numerous pathological conditions. The overexpression of LRP/LR on various cancerous cell lines plays critical roles in tumour metastasis and angiogenesis. This study investigated whether LRP/LR is implicated in the maintenance of cellular viability in lung and cervical cancer cell lines. Here we show a significant reduction in cellular viability in the aforementioned cell lines as a result of the siRNA-mediated downregulation of LRP. This reduction in cellular viability is due to increased apoptotic processes, reflected by the loss of nuclear integrity and the significant increase in the activity of caspase-3. These results indicate that LRP/LR is involved in the maintenance of cellular viability in tumorigenic lung and cervix uteri cells through the blockage of apoptosis. Knockdown of LRP/LR by siRNA might represent an alternative therapeutic strategy for the treatment of lung and cervical cancer.en_ZA
dc.description.librarianNCS2016en_ZA
dc.description.sponsorshipNRF, South Africa. MRC, South Africa.en_ZA
dc.identifier.citationMoodley, K. and Weiss, S.F.T. 2013. Downregulation of the Non-Integrin Laminin Receptor Reduces Cellular Viability by Inducing Apoptosis in Lung and Cervical Cancer Cells. PLoS ONE 8(3):e57409.en_ZA
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10539/21254
dc.journal.titlePLoS ONEen_ZA
dc.journal.volume8en_ZA
dc.language.isoenen_ZA
dc.publisherPublic Library of Science.en_ZA
dc.rights© 2013 Moodley, Weiss. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.subject37 kDa laminin receptor precursoren_ZA
dc.subject67 kDa laminin receptoren_ZA
dc.subjectcaspase 3en_ZA
dc.subjectlaminin receptoren_ZA
dc.subjectsmall interfering RNAen_ZA
dc.subjectunclassified drugen_ZA
dc.subjectapoptosisen_ZA
dc.subjectcancer cellen_ZA
dc.subjectcell nucleusen_ZA
dc.subjectcell surfaceen_ZA
dc.subjectCell Lineen_ZA
dc.subjectTumoren_ZA
dc.subjectCell Survivalen_ZA
dc.subjectDown-Regulationen_ZA
dc.subjectEnzyme Activationen_ZA
dc.subjectFemaleen_ZA
dc.subjectGene Expression Regulationen_ZA
dc.subjectNeoplasticen_ZA
dc.subjectHeLa Cellsen_ZA
dc.subjectHumansen_ZA
dc.subjectLung Neoplasmsen_ZA
dc.subjectReceptorsen_ZA
dc.subjectLamininen_ZA
dc.subjectRNAen_ZA
dc.subjectUterine Cervical Neoplasmsen_ZA
dc.titleDownregulation of the Non-Integrin Laminin Receptor Reduces Cellular Viability by Inducing Apoptosis in Lung and Cervical Cancer Cells.en_ZA
dc.typeArticleen_ZA
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