Cardiac effects of high dose androgenic steroid administration.

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dc.contributor.authorTrifunovic, Boris
dc.date.accessioned2019-05-30T08:02:53Z
dc.date.available2019-05-30T08:02:53Z
dc.date.issued1998
dc.descriptionA thesis submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg, for the Degree of Doctor of Philosophy.en_ZA
dc.description.abstractAndrogenic steroids are commonly used at supraphysiological doses by athletes and body builders. There are an increasing number of reports of sudden cardiac death and myocardial infarcts associated with androgenic steroid abuse. In this thesis the effect of an androgenic steroid on cardiac mechanical performance, cellular function and interstitial properties was examined in rats. A biweekly intramuscular injection of nandrolone decanoate (5 mg/kg) (steroid) for three months to sedentary rats supressed testosterone production. Chronic steroid administration increased left ventricular end diastolic (LVED) chamber stiffness (k). as determined both ill vivo in anaesthetised, open-chest animals. using piezoelectric ultrasonic transducers to measure LV dimensions, as well as ex vivo, using an isolated, perfused, constant flow, isovolumic LV preparation. The increased LVED chamber k was attributed to changes in myocardial properties. as myocardial ED k was also increased. The altered L ED chamber performance mediated by chronic steroid administration subsequently resulted in a decreased slope of the LV stroke work-LVEDP relation (determined in vivo), a preload-independent index of LV systolic performance. however, load-insensitive indices of LV systolic performance, assessed both in vivo and ex vivo (slopes of LV end systolic or peak systolic pressure-dimension. pressure-volume and stress-strain relations) were either modestly increased or unchanged following steroid administration. (Abbreviation abstract)en_ZA
dc.description.librarianAndrew Chakane 2019en_ZA
dc.identifier.urihttps://hdl.handle.net/10539/27353
dc.language.isoenen_ZA
dc.subjectHeart Function Tests.en_ZA
dc.subjectAnabolic Steroids adverse effects.en_ZA
dc.titleCardiac effects of high dose androgenic steroid administration.en_ZA
dc.typeThesisen_ZA
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