An assessment of the effectiveness of Andolex-C ® mouth rinse on oral palliation in HIV-infected patients
Date
2008-11-04T12:34:12Z
Authors
Malele, Yolanda
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Abstract
Title: An assessment of the effectiveness of Andolex-C ® mouth rinse on oral palliation
in HIV-infected patients.
Background: The majority of HIV-infected patients present with oral lesions associated
with the disease. HIV-infected patients experience profound disorders like oral infections
and ulcerations, discomfort and greater levels of social impact than non-HIV patients as a
result of oral lesions. Studies have indicated that mouth pain is a significant symptom
reported by HIV-infected patients. In order to relieve pain and discomfort and improve
quality of life, management of HIV-infected patients should include relief of mouth pain,
discomfort as well as the social and psychological distress caused by the oral lesions.
Objectives: To determine the prevalence of oral lesions associated with HIV among a
cohort of HIV-infected patients. To assess the effectiveness of Andolex-C® mouth rinse
on oral palliation in HIV-infected patients.
Methods: The intervention of Andolex C® mouth rinse plus a proven preventive oral
hygiene regimen was compared to an established oral hygiene intervention. Two hundred
and ninety nine patients were randomly assigned into Groups 1 and 2. Patients in Group
1 were given toothbrushes and toothpaste and oral hygiene instruction ‘routine oral
hygiene package’. Those in Group 2 received Andolex-C® mouth rinse in addition to the
‘routine oral hygiene package’ given to the first group. A baseline assessment of mouth
pain and/or discomfort was done via a clinical examination and an assessment of quality
of life was done using the Oral Health Impact Profile (OHIP) questionnaire. The
intervention was carried out over a four week period after which a follow-up assessment
was done using the same tools. Comparison of baseline versus post-treatment scores was
performed to determine impact of intervention in both groups.
Results: The prevalence of combined candidal lesions was 71.6% of which
Pseudomembranous candidiasis was 43.2%. Erythematous candidiasis and angular
cheilitis were the next commonly seen, each with an equal prevalence of 14.2 %.
Group 2 (Andolex-C® mouth rinse) showed a statistically significant improvement in
quality of life on all subscales related to functioning, pain, psychological and social
aspects when using the OHIP index. The patients demonstrated substantial reduction of
[64%] of mouth pain and/or discomfort and a 73% reduction of oral lesions compared to
Group 1 where there was a much smaller [22%] reduction of mouth pain and/or
discomfort and a 40% reduction of the oral lesions.
Conclusion: Andolex-C® mouth rinse improved the quality of life of HIV-infected
patients who presented with mouth pain and/or discomfort and demonstrated that in
combination with proper oral care and good hygiene habits, this regimen could be
recommended for oral palliation in HIV positive patients.
Description
Keywords
oral palliation, Benzydamine and Chlorhexidine mouth rinse, Oral HIV