Trans-ethnic genomic informed risk assessment for Alzeheimer's disease: an International Hundred K+ Cohorts Consortium study.

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dc.contributor.authorPatrick M Sleiman
dc.contributor.authorHui-Qi Qu
dc.contributor.authorJohn J Connolly
dc.contributor.authorFrank Mentch
dc.contributor.authorAlexandre Pereira
dc.contributor.authorPaulo A Lotufo
dc.contributor.authorStephen Tollman
dc.contributor.authorAnanyo Choudhury
dc.contributor.authorMichele Ramsay
dc.contributor.authorNorihiro Kato
dc.contributor.authorKouichi Ozaki
dc.contributor.authorRisa Mitsumori
dc.contributor.authorJae-Pil Jeon
dc.contributor.authorChang Hyung Hong
dc.contributor.authorSang Joon Son
dc.contributor.authorHyun Woong Roh
dc.contributor.authorDong-Gi Lee
dc.contributor.authorNaaheed Mukadam
dc.contributor.authorIsabelle F Foote
dc.contributor.authorCharles R Marshall
dc.contributor.authorAdam Butterworth
dc.contributor.authorBram P Prins
dc.contributor.authorJoseph T Glessner
dc.contributor.authorHakon Hakonarson
dc.date.accessioned2024-03-04T10:12:23Z
dc.date.available2024-03-04T10:12:23Z
dc.date.issued2023-07-14
dc.description.abstractBackground: As a collaboration model between the International HundredK+ Cohorts Consortium (IHCC) and the Davos Alzheimer's Collaborative (DAC), our aim was to develop a trans-ethnic genomic informed risk assessment (GIRA) algorithm for Alzheimer's disease (AD). Methods: The GIRA model was created to include polygenic risk score calculated from the AD genome-wide association study loci, the apolipoprotein E haplotypes, and non-genetic covariates including age, sex, and the first three principal components of population substructure. Results: We validated the performance of the GIRA model in different populations. The proteomic study in the participant sites identified proteins related to female infertility and autoimmune thyroiditis and associated with the risk scores of AD. Conclusions: As the initial effort by the IHCC to leverage existing large-scale datasets in a collaborative setting with DAC, we developed a trans-ethnic GIRA for AD with the potential of identifying individuals at high risk of developing AD for future clinical applications.
dc.description.librarianPM2023
dc.facultyFaculty of Health Sciences
dc.identifier.urihttps://hdl.handle.net/10539/37748
dc.language.isoen
dc.schoolPublic Health
dc.subjectAlzheimer’sdisease,datasharing,femaleinfertility,genomicinformedriskassessment,minoritypopulation,polygenicriskscore,thyroid,trans-ethnic
dc.titleTrans-ethnic genomic informed risk assessment for Alzeheimer's disease: an International Hundred K+ Cohorts Consortium study.
dc.typeArticle
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