The Novel Coronavirus and Haemostatic abnormalities pathophysiology clinical manifesttations and treatment recommendations

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dc.citation.doi10.1007/978-3-030-59261-5
dc.citation.epage180
dc.citation.spage173
dc.contributor.authorSusan Louw
dc.contributor.authorBarry Jacobson
dc.contributor.authorElizabeth Mayne
dc.contributor.authorTracey Wiggill
dc.date.accessioned2023-02-28T09:38:16Z
dc.date.available2023-02-28T09:38:16Z
dc.departmentMolecular Medicine and Haematology
dc.description.abstractThe COVID-19 pandemic, caused by the SARS-C0V-2 virus, was initially considered and managed in a similar manner to the previous SARS epidemic as they are both caused by coronaviruses. What has now become apparent is that a major cause of morbidity and mortality in COVID-19 is abnormal thrombosis. This thrombosis occurs on a macro- and microvascular level and is unique to this disease. The virus has been demonstrated in the endothelium of the pulmonary alveoli and as such is thought to contribute to the devastating respiratory complications encountered. D-dimer concentrations are frequently raised in COVID to levels not frequently seen previously. The optimal anticoagulation treatment in COVID remains to be determined, and the myriad of pathophysiologic effects caused by this virus in the human host have also yet to be fully elucidated.
dc.facultyFaculty of Health Sciences
dc.identifier.citationLouw S, Jacobson BF, Mayne ES, Wiggill TM. The Novel Coronavirus and Haemostatic Abnormalities: Pathophysiology, Clinical Manifestations, and Treatment Recommendations. Adv Exp Med Biol. 2021;1321:173-180. doi:10.1007/978-3-030-59261-5_15
dc.identifier.issn0065-2598
dc.identifier.urihttps://hdl.handle.net/10539/34707
dc.journal.titleAdvances in experimental medicine and biology
dc.journal.volume1321
dc.rights© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
dc.schoolSchool of Pathology
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectCoagulopathy
dc.subjectThrombosis
dc.subjectBiomarkers
dc.subjectTreatment
dc.subject.otherSDG-3: Good health and well-being
dc.titleThe Novel Coronavirus and Haemostatic abnormalities pathophysiology clinical manifesttations and treatment recommendations
dc.typeArticle
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